基于微分段技术分析单根头发中42种精神活性物质
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纪佼佼, 徐多麒, 向平, 严慧, 沈敏
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Analysis of Forty-Two Psychoactive Substances in a Single Hair by Micro-Segmental Technique
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Jiao-jiao JI, Duo-qi XU, Ping XIANG, Hui YAN, Min SHEN
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表4 头发中42种精神活性物质的精密度、准确度、回收率和基质效应 (%)
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Tab. 4 Precision， accuracy， recovery and matrix effect of 42 psychoactive substances in hair
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| 化合物 | 浓度/（pg·mm-1） | 日内（n=6） | 日间（n=24） | 基质效应 （n=6） | 提取回收率 （n=6） |
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| 精密度 | 准确度 | 精密度 | 准确度 |
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| 苯丙胺 | 5 | 5.7 | 92.5 | 6.2 | 94.8 | 90.1 | 88.2 | | 250 | 6.7 | 92.0 | 8.1 | 94.3 | 89.0 | 87.6 | | 甲基苯丙胺 | 20 | 7.8 | 97.5 | 12.6 | 91.3 | 85.0 | 92.5 | | 250 | 4.7 | 90.9 | 12.2 | 94.1 | 93.8 | 85.3 | | 氯胺酮 | 10 | 2.9 | 92.7 | 8.1 | 91.6 | 80.4 | 90.7 | | 250 | 3.0 | 91.7 | 6.5 | 95.1 | 86.3 | 84.5 | | 吗啡 | 20 | 9.8 | 87.7 | 9.4 | 91.6 | 88.1 | 76.3 | | 250 | 2.3 | 91.0 | 5.4 | 92.6 | 89.2 | 83.2 | | O6-单乙酰吗啡 | 20 | 3.4 | 92.3 | 5.9 | 104.2 | 91.5 | 83.6 | | 250 | 3.9 | 93.5 | 8.4 | 92.2 | 87.6 | 77.2 | | 可卡因 | 5 | 4.9 | 94.5 | 7.6 | 99.2 | 90.2 | 84.1 | | 250 | 3.9 | 97.2 | 6.1 | 105.3 | 92.4 | 79.2 | | 苯甲酰爱康宁 | 2 | 4.0 | 93.4 | 5.3 | 94.8 | 93.4 | 91.2 | | 250 | 2.9 | 99.5 | 4.2 | 98.0 | 94.5 | 90.8 | | 麦角二乙胺 | 1 | 6.1 | 102.1 | 8.8 | 105.2 | 87.2 | 80.5 | | 250 | 4.9 | 96.7 | 6.4 | 102.2 | 86.4 | 76.5 | | 芬太尼 | 20 | 5.2 | 92.0 | 9.4 | 89.5 | 71.3 | 79.2 | | 250 | 7.9 | 90.5 | 11.2 | 94.5 | 85.4 | 76.2 | | 地芬尼多 | 10 | 5.0 | 95.1 | 3.1 | 92.1 | 89.4 | 85.4 | | 250 | 4.1 | 94.3 | 9.4 | 91.5 | 80.6 | 76.2 | | 氟硝西泮 | 2 | 2.4 | 101.9 | 5.3 | 109.2 | 95.4 | 90.6 | | 250 | 5.1 | 97.6 | 6.9 | 96.1 | 95.6 | 91.2 | | 7-氨基氟硝西泮 | 2 | 3.9 | 97.1 | 10.5 | 94.7 | 94.5 | 90.6 | | 250 | 4.5 | 93.6 | 5.8 | 97.5 | 98.2 | 92.4 | | 三唑仑 | 1 | 3.9 | 102.9 | 8.2 | 109.1 | 86.3 | 88.6 | | 250 | 8.4 | 101.3 | 10.8 | 106.8 | 94.3 | 91.5 | | α-羟基三唑仑 | 5 | 7.1 | 96.1 | 11.2 | 93.9 | 88.5 | 76.2 | | 250 | 6.9 | 97.4 | 10.6 | 95.1 | 85.1 | 78.5 | | 可待因 | 20 | 7.9 | 94.9 | 7.9 | 88.2 | 81.2 | 73.5 | | 250 | 10.2 | 98.4 | 4.9 | 99.2 | 84.9 | 80.2 | | 地西泮 | 1 | 8.1 | 98.3 | 11.5 | 100.5 | 89.5 | 88.2 | | 250 | 6.1 | 102.6 | 8.3 | 104.9 | 92.1 | 91.3 | | 去甲地西泮 | 5 | 4.2 | 98.3 | 9.2 | 95.1 | 90.1 | 74.2 | | 250 | 5.7 | 92.3 | 8.0 | 106.0 | 85.9 | 89.6 | | 替马西泮 | 10 | 3.8 | 97.4 | 5.2 | 98.1 | 97.2 | 86.1 | | 250 | 2.4 | 92.1 | 4.5 | 104.5 | 94.1 | 88.8 | | 奥沙西泮 | 20 | 5.1 | 103.5 | 12.7 | 103.6 | 94.5 | 91.6 | | 250 | 11.8 | 96.8 | 10.2 | 90.4 | 95.6 | 84.5 | | 阿普唑仑 | 2 | 5.1 | 98.1 | 7.7 | 96.6 | 88.5 | 76.9 | | 250 | 4.0 | 97.0 | 6.5 | 98.6 | 84.6 | 77.9 | | α-羟基阿普唑仑 | 10 | 8.2 | 95.0 | 11.6 | 90.5 | 85.9 | 88.6 | | 250 | 6.9 | 93.1 | 10.5 | 94.2 | 89.2 | 79.9 | | 氯硝西泮 | 5 | 3.2 | 97.2 | 6.8 | 96.6 | 94.5 | 90.6 | | 250 | 4.0 | 96.1 | 5.5 | 93.7 | 92.1 | 89.7 | | 7-氨基氯硝西泮 | 2 | 4.9 | 93.5 | 5.6 | 96.2 | 94.2 | 94.9 | | 250 | 5.1 | 94.6 | 9.1 | 96.8 | 96.2 | 89.8 | | 艾司唑仑 | 1 | 1.5 | 95.1 | 5.3 | 98.6 | 102.4 | 92.5 | | 250 | 3.9 | 94.2 | 5.6 | 100.9 | 100.8 | 91.8 | | 劳拉西泮 | 20 | 2.1 | 88.4 | 5.6 | 104.6 | 105.2 | 98.2 | | 250 | 5.1 | 90.6 | 9.4 | 106.6 | 101.5 | 91.5 | | 咪达唑仑 | 1 | 4.9 | 97.3 | 7.1 | 94.8 | 98.2 | 92.5 | | 250 | 2.7 | 100.9 | 8.5 | 97.7 | 103.5 | 86.9 | | 硝西泮 | 5 | 4.8 | 97.5 | 9.4 | 93.2 | 109.3 | 89.9 | | 250 | 5.1 | 90.1 | 8.1 | 103.2 | 107.6 | 84.5 | | 7-氨基硝西泮 | 10 | 4.1 | 105.7 | 9.4 | 98.5 | 99.6 | 88.8 | | 250 | 2.9 | 94.5 | 6.9 | 91.4 | 97.2 | 76.0 | | 唑吡坦 | 0.5 | 4.2 | 99.2 | 6.7 | 95.4 | 102.1 | 89.0 | | 250 | 2.9 | 100.6 | 5.4 | 99.3 | 97.8 | 84.9 | | 西酞普兰 | 2 | 4.9 | 98.5 | 5.9 | 105.3 | 94.2 | 86.9 | | 250 | 7.3 | 96.3 | 8.4 | 96.2 | 98.7 | 83.1 | | 苯海拉明 | 2 | 4.5 | 102.4 | 6.3 | 108.6 | 89.4 | 81.1 | | 250 | 5.2 | 94.2 | 6.9 | 102.1 | 94.2 | 76.2 | | 右美沙芬 | 10 | 3.6 | 97.5 | 7.5 | 98.0 | 86.5 | 81.9 | | 250 | 5.1 | 93.2 | 8.4 | 106.7 | 87.2 | 77.8 | | 氯氮平 | 2 | 1.9 | 98.2 | 6.0 | 99.4 | 91.6 | 87.2 | | 250 | 4.2 | 97.2 | 5.5 | 93.8 | 94.2 | 81.7 | | 东莨菪碱 | 0.5 | 2.9 | 86.7 | 5.4 | 92.1 | 89.4 | 86.2 | | 250 | 8.4 | 104.9 | 10.5 | 106.0 | 102.8 | 82.4 | | 右美托咪定 | 5 | 4.6 | 98.1 | 11.2 | 97.2 | 91.5 | 71.5 | | 250 | 3.5 | 96.2 | 5.6 | 93.4 | 87.5 | 79.1 | | 曲马多 | 20 | 9.4 | 91.5 | 6.9 | 105.2 | 94.2 | 68.1 | | 250 | 2.7 | 94.5 | 3.9 | 93.6 | 88.5 | 71.1 | | 安替比林 | 20 | 4.9 | 86.5 | 7.5 | 103.6 | 105.4 | 84.3 | | 250 | 1.8 | 90.5 | 2.8 | 94.5 | 94.1 | 88.4 | | 卡马西平 | 5 | 2.1 | 98.4 | 5.7 | 97.9 | 102.7 | 75.4 | | 250 | 3.8 | 98.2 | 7.8 | 96.3 | 97.5 | 82.6 | | 奥卡西平 | 10 | 3.6 | 97.1 | 9.3 | 96.5 | 100.2 | 89.4 | | 250 | 4.2 | 102.9 | 6.5 | 100.1 | 104.6 | 79.2 | | 尼美西泮 | 2 | 5.1 | 98.2 | 8.8 | 96.8 | 88.9 | 87.2 | | 250 | 4.6 | 101.7 | 6.7 | 105.5 | 89.4 | 84.9 | | 喹硫平 | 2 | 1.7 | 98.2 | 6.0 | 101.8 | 102.7 | 94.2 | | 250 | 2.0 | 97.2 | 7.4 | 101.7 | 103.8 | 90.8 | | 米氮平 | 0.5 | 1.9 | 98.3 | 3.1 | 97.2 | 111.7 | 86.4 | | 250 | 2.3 | 103.2 | 9.7 | 103.5 | 102.7 | 91.6 |
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