基于代谢组学分析急性心肌梗死大鼠尿液代谢物变化
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陈念念, 余娇芳, 吴鹏, 罗丽, 白雅琴, 王利凯, 李晓倩, 李展鹏, 高彩荣, 郭相杰
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Urine Metabolites Changes in Acute Myocardial Infarction Rats via Metabolomic Analysis
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Nian-nian CHEN, Jiao-fang YU, Peng WU, Li LUO, Ya-qin BAI, Li-kai WANG, Xiao-qian LI, Zhan-peng LI, Cai-rong GAO, Xiang-jie GUO
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表2 AMI和HAMI组VIP值排名前五的差异代谢物
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Tab. 2 The top 5 differential metabolites in VIP values between the AMI and HAMI groups
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| 组别 | 排序 | 代谢物 | 代谢物中文名称 | CAS号 | VIP值 | P值 | 趋势 |
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| AMI | 1 | 3-indoleacrylic acid | 3-吲哚丙烯酸 | 29953-71-7 | 7.290 | 0.048 | ↑ | | 2 | L-ascorbic acid 2-sulfate | L-抗坏血酸2-硫酸盐 | 37627-95-5 | 6.590 | 0.010 | ↑ | | 3 | 4-guanidinobutyric acid | 4-胍基丁酸 | 463-00-3 | 4.360 | 0.022 | ↓ | | 4 | 2-hydroxyphenylalanine | 2-羟基苯丙氨酸 | 2370-61-8 | 4.130 | 0.046 | ↑ | | 5 | hypoxanthine | 次黄嘌呤 | 68-94-0 | 2.360 | 0.001 | ↑ | | HAMI | 1 | hippuric acid | 马尿酸 | 495-69-2 | 17.800 | <0.001 | ↑ | | 2 | creatinine | 肌酐 | 60-27-5 | 12.740 | <0.001 | ↑ | | 3 | creatine | 肌酸 | 57-00-1 | 9.180 | 0.007 | ↓ | | 4 | D-（+）-malic acid | D-（+）-苹果酸 | 636-61-3 | 6.350 | 0.048 | ↑ | | 5 | genistein | 染料木黄酮 | 446-72-0 | 5.630 | 0.024 | ↑ |
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