基于不同STR分型试剂盒的肿瘤组织身源鉴定方法

吴黎明, 陈安琪, 张素华, 李成涛

Identification Methods of Tumor Tissue Origin Based on Different STR Typing Kits

Li-ming WU, An-qi CHEN, Su-hua ZHANG, Cheng-tao LI

表4 8个试剂盒区分PC组与UI、FS、PO组所需的A2阈值

Tab. 4 The A2 thresholds required for 8 kits to distinguish the PC group from the UI， FS and PO groups

试剂盒 基因座数量/个 PC vs UI PC vs FS PC vs PO A2 灵敏度/% 特异度/% 约登指数 A2 灵敏度/% 特异度/% 约登指数 A2 灵敏度/% 特异度/% 约登指数 AmpFℓSTRTM IdentifilerTM 15 ≥9 100.00 96.51 96.51 ≥10 100.00 96.36 96.36 ≥7 100.00 98.18 98.18 AmpFℓSTRTM SinofilerTM 15 ≥9 100.00 97.26 97.26 ≥11 98.18 98.18 96.36 ≥8 100.00 97.27 97.27 AGCU EX22 21 ≥11 100.00 97.58 97.58 ≥13 100.00 98.18 98.18 ≥10 100.00 97.27 97.27 AmpFℓSTRTM NGM 15 ≥10 98.18 99.58 97.76 ≥9 100.00 96.36 96.36 ≥8 100.00 97.27 97.27 PowerPlex® 16 15 ≥9 100.00 98.18 98.18 ≥10 98.18 96.36 94.54 ≥8 100.00 97.27 97.27 PowerPlex® 21 20 ≥10 100.00 95.22 95.22 ≥13 100.00 96.36 96.36 ≥10 100.00 99.09 99.09 Goldeneye® 20A 19 ≥10 100.00 96.46 96.46 ≥13 100.00 98.18 98.18 ≥10 100.00 99.09 99.09 SiFa-23plex 21 ≥11 100.00 97.38 97.38 ≥13 100.00 96.36 96.36 ≥10 100.00 98.18 98.18