HPLC-MS/MS法检测尿液中依托咪酯及依托咪酯酸

何天夫, 朱焕慧, 田源源, 金银霜, 林贤文, 王松才

Detection of Etomidate and Etomidate Acid in Urine Using HPLC-MS/MS Method

Tian-fu HE, Huan-hui ZHU, Yuan-yuan TIAN, Yin-shuang JIN, Xian-wen LIN, Song-cai WANG

表4 尿液中添加依托咪酯和依托咪酯酸的基质效应、回收率及稳定性 (%)

Tab. 4 Matrix effect， recovery rate and stability of etomidate and etomidate acid in urine

目标物 质量浓度/（ng·mL-1） 基质效应 回收率 冻融稳定性 长期稳定性 7 d 14 d 28 d 依托咪酯 0.5 18.47 96.64 110.23 103.51 110.65 91.26 5 7.29 93.07 102.34 100.26 97.12 89.84 50 5.42 84.25 98.49 99.55 97.24 90.75 依托咪酯酸 1 8.29 107.43 91.77 101.91 90.68 105.79 10 7.11 110.26 102.31 96.36 93.80 92.16 100 10.73 97.82 103.68 100.43 94.01 88.23