Abstract: After death, the lysis and disappearance of hepatic glycogen of the liver are closely linked with the time. All kind of sudden death, inclouding the death by violence, acute drug poisoning and drowing. Within 3 hours after death, the no obvious hepatic gycogen loss can be seen. Between 3-12 hours after death, the hepatic glycogen loss was recognized in the form of macula (likeplaque which centred around the interlobular portal area. The glycogen macula-like losing area gredually expand during this phase. In the mean time, the activity of Kupffer's cell became vivid. It gulfed (phago- cytosis) a lot of glycogen into its cytoplasm. Between 12-24 hours after death, the hepatic glycogen diffused into the form of small granules all over the hepatic lobule and the amout of glycogen was redused to only one fifth that of the immediate death. 70 hours after death, the hepatic glycogen was disappeared completely. However, the exhausting death, for example, death by hunger, the phase of lysis and disappearance of hepatic glycogen is different from that of menti- oned above, usually, there are no or very little hepatic glycogen in the cytopla- sm of liver cell at all.