法医学杂志

法医学杂志 ›› 1994, Vol. 0 ›› Issue (1): 0-0.

• 论文 •    

脑死亡法医病理学研究──实验性颅内高压致死病理形态学观察

李如波，李德祥，姜景涛   

  1. 中国医科大学法医学系
  • 发布日期:1994-02-25 出版日期:1994-02-28

FORENSIC PATHOLOGICAL STUDY OF BRAIN DEATH:MORPHOLOGICAL OBSERVATION OF DEAD BRAIN INDUCED BY EXPERIMENTAL INTRACRANIAL HYPERTENSION

LI RUBO, LI DEXIANG,JANG JINGTAO. (DEPARTMENT OF FORENSIC PATHOLOGY,FACULTY OF FORENSIC MEDICINE. CHINA MEDICAL UAIVERSITY; SHENYANG 110001).   

  • Online:1994-02-25 Published:1994-02-28

摘要： 本文采用３３只家猫，颅内硬脑膜外埋置胶囊，按颅腔容积１０％注水，产生持续性颅内高压，致使：１．瞳孔散大、光反射消失，呼吸减慢甚致停止，脑电平直；２．枕骨大孔疝形成，疝下的小脑组织碎断、播散到脊髓蛛网膜下腔；３．随着人工呼吸时间（１—２４小时）的延长，神经细胞坏死及溶解增多，９～１２小时遍及全脑．因此．持续性颅内高压可致脑疝。全脑功能不可逆性丧失及神经细胞广泛性坏死、溶解，已处于脑死亡状态，时限是９—１２小时．

关键词: 脑死亡, 颅内高压, 脑疝, 神经细胞坏死和溶解

Abstract: In order to study the lesions and pathogenesis of braindsath. the experimcnts were performed in 33 cats to causerersistent intracranial hypertension by extradural inflatingballon. The animals were divided into 7 groups accordingto the duration maintained on the respirator. The resultsshow: (1) Dilated and fixed pupils. cessation of respiration and flattening of EEG, (2) A varying degree of cerebral herniations, especially the herniation of foramenmagnum and dissemination of the herniated fragments ofcarebellar tonsillar tissue into the spinal subarachnoidspace (3) The longer of the duration maintained on respirator. the more severe of the neuronal necrosis andautolysis which occured in whole brain at 9-12 hours.

Key words: Brain death, Intracranial hypertension, Carebral herniation, Neuronal necrcsis and autolysis