法医学杂志

法医学杂志 ›› 1995, Vol. 0 ›› Issue (4): 0-0.

• 论文 •    

根据S—100蛋白阳性胶质细胞的变化判断脑挫伤时间的实验研究

汪德文，张国华，姜景涛，李如波，陈怀芳，吴旭，刘桂琴   

  1. 中国医科大学法医病理教研室，中国医科大学第三临床学院内科
  • 发布日期:1995-08-25 出版日期:1995-08-28

Experimental Study on Time Estimation of Brian Contusion through S-100 Protein Changes of Positive Glia

WANG DEWEN; LI RUBO; JIANG JINTAO; ZHANG GUOHUA; CHEN HUIFANG (DEPARTMENT OF FORENSIC PATHOLOGY, FACULTY OF FORENSIC MEDICINE, CHINA MEDICAL UNIVERSITY; SHENYANG, 110001)   

  • Online:1995-08-25 Published:1995-08-28

被引次数

72

摘要： 本文米用免疫组织化学ＡＢＣ法，观察了２４只大白鼠脑挫伤不同时间的胶质细胞特异性标志物Ｓ－１００蛋白的变化。结果表明，挫伤２天后Ｓ—１００阳性胶质细胞的胞体开始增大，突起不明显，随着脑挫伤时间的延长，胞体增大，突起明显的Ｓ—１００阳性胶质细胞数量明显增加，到第五天时达高峰，在脑挫伤的周围区均为胞林大、突起明显的Ｓ—１００阳性细胞，此结果表明Ｓ－１００蛋白的变化可用于挫伤后时间的判断。

关键词: 脑挫伤, 免疫组化, S—100蛋白。

Abstract: S-100 protein positive glia of 24 contused rats' beam c was observed at different intervals by immunothistochemical ABC method. The results showed that 2 days aftet contusion S-100 protein positive glia was enlarged with no distinct process. With longer duration of the cerebral contusion, the glia was enlarged and increased markedly and peaked at 5 days. The S-100 protein positive enlarged glia were distributed in periphery of contusive area. It is concluded that the S-100 protein can be used to estimate the time of brain contusion.

Key words: brain contusion, immunohistochemistry, S -100 protein