法医学杂志

法医学杂志 ›› 1996, Vol. 0 ›› Issue (1): 0-0.

• 论文 •    

乌头碱在兔尸中的降解动力学研究

徐威，胡炳蔚，车向明，王多劳   

  1. 西安医科大学法医系毒理室，西安医科大学第一附属医院外科教研室，西安医科大学卫生系统计学教研室
  • 发布日期:1996-02-25 出版日期:1996-02-28

Study of Aconitine Degradation Kinetics in Rabbit Corpses

XU WEI; HA BINGWEI; CHE XINNGMING;WANG DUOLAO (FACULLY OF FORENSIC MEDICINE, XI'AN MED ICAL UNIVERSITY; SHAANXI 710061)   

  • Online:1996-02-25 Published:1996-02-28

被引次数

8

摘要： 本文研究了灌服短柄乌头（ＡｃｏｎｉｔｕｍｂｒａｃｈｙｐｏｄｕｍＤｉｅｌｓ，简称ＡｂＤ）后，乌头碱（Ａ－ｃｏｎｉｔｉｎｅ，简称ＡＣ）在４℃保存兔厂中的降解动力学规律。结果显示，乌头碱在克厂中的降解符合表观二级动力学过程，乌头碱在肝、肾中的降解动力学方程分别为：Ｃ－１（肝）＝０．０３３９（ｔ—５）＋０．１９１８，ｃ－１（肾）＝０．０７８８（ｔ—５）＋０．５１７６，其半衰期分别为５．６６和６．５７天。

关键词: 降解动力学, 动态变化, 乌头碱

Abstract: Aconitine (AC) degradation kinetics in tissues of rabbit corpses stored at 4℃ after administrated Aconitum Brachypodum Diets AbD orally was studied' The result showed that AC degradation process in rabbit corpses is apparent two-order degradation kinetics'AC degradation kinetics equations in liver and kidney arc C-1 (liver) = 0. 0339 (t-5) + 0. 1918 ， C-1 (kid ney) = 0. 0788t + 0.5176, the half lives of them are 5. 66 and 6.47 days respectively.

Key words: degradation kinetics, dynamic change, aconitine, acute toxicity