法医学杂志

法医学杂志 ›› 2000, Vol. 16 ›› Issue (1): 21-23+6.

• 论文 • 上一篇    下一篇

中毒致死者体内芬氟拉明的GC/NPD、GC/MS法测定

孙亚娟,吴侔天,施云   

  1. 司法部司法鉴定科学技术研究所!上海200063,司法部司法鉴定科学技术研究所!上海200063,华东政法学院!上海200042
  • 发布日期:2000-02-25 出版日期:2000-02-28

Determination of fenfluramine in corpse using GC/NPD and GC/MS

SUN YAJUAN,ET AL.(INSTITUTE OF FORENSIC SCIENCES, MINISTRY OF JUSTICE, SHANGHAI 200063,P.R.CHINA)   

  • Online:2000-02-25 Published:2000-02-28

被引次数

2

摘要： 建立了生物检材中芬氟拉明的定性定量分析方法。体液及脏器组织经有机溶剂提取后 ,用GC/MS法进行药物筛选、定性 ,生物检材中的芬氟拉明浓度用4 -苯丁胺作内标、GC/NPD法测定。测得芬氟拉明中毒致死者的血液、尿液、肝等组织中浓度分别为7.8μg/ml、64.2μg/ml、31.3μg/g。并对尸体解剖所见及方法可行性进行讨论

关键词: 芬氟拉明, 血, 尿, GC/MS, GC/NPD

Abstract: A method was described for the determination of fenfluramine by GC/MS in blood, urine, liver, lung, kidney and heart tissues. After liquid-liquid extraction of fenfluramine in the specimens obtained from autopsy, the samples were qualitatively identified by GC/MS, and quantitatively determined by GC/NPD. 4-phenyl butylamine was used as internal standard. The concentrations of fenfluramine in blood, urine and liver were 7.8μg/ml, 64.2 μg/ml and 31.3 μg/g respectively. The findings of autopsy and the results of toxicological analysis were also discussed.

Key words: fenfluramine, liquid-liquid extraction, blood, urine, GC/MS, GC/NPD