法医学杂志

法医学杂志 ›› 2007, Vol. 0 ›› Issue (1): 23-25.

• 论文 • 上一篇    下一篇

钾中毒致死家兔病理形态学变化

朱新菊;陈利萍;李开;徐永城;柯咏;王振原;   

  1. 西安交通大学医学院法医学系,西安交通大学医学院法医学系,南京医科大学法医学系,西安交通大学医学院法医学系,西安交通大学医学院法医学系,西安交通大学医学院法医学系 陕西西安710061,镇江市公安局刑警支队,江苏镇江212000,陕西西安710061,江苏南京210029,陕西西安710061,陕西西安710061,陕西西安710061
  • 发布日期:2007-02-25 出版日期:2007-02-28

Morphological Changes in Rabbits Died of Potassium Intoxication

ZHU XIN-JU1,2,CHEN LI-PING1,LI KAI3,XU YONG-CHENG1,KE YONG1,WANG ZHEN-YUAN1(1.DEPARTMENT OF FORENSIC MEDICINE,SCHOOL OF MEDICINE,XI'AN JIAOTONG UNIVERSITY,XI'AN 710061,CHINA;2.ZHENJIANG PUBLIC SECURITY BUREAU,ZHENJIANG 212000,CHINA;3.DEPARTMENT OF FORENSI   

  • Online:2007-02-25 Published:2007-02-28

摘要： 目的研究钾中毒致死家兔的尸体组织形态学变化特征,为钾中毒致死的法医学鉴定提供客观依据。方法采用浓度为0.3%和1%的氯化钾溶液,分别以全速和100滴/min的速度静脉输注家兔至其死亡,肉眼、光镜及透射电镜下观察尸体心、脑、肾形态学变化,比较两种不同输液方式下形态学变化的差异。结果输钾致死的家兔心脏显著扩张淤血,心肌呈缺血缺氧改变,心肌肌节长短不一,Z线变宽、聚集或消失;肾小球毛细血管收缩,包曼氏囊扩张,足突绒毛化、融合;脑组织中可见凋亡及吞噬现象。上述改变均以1%组为著。结论心脏及肾脏的一些形态学改变可作为钾中毒死亡法医学鉴定的重要依据。

关键词: 钾中毒, 超微结构, 形态学变化

Abstract: Objective Morphologic features of the corpse of rabbits died of potassium intoxication were studied in order to elucidate an objective evidence for forensic determination of death caused by potassium intoxication.Methods Macroscopic,microscopic,and ultrastructural(by transmission electron microscopy) changes were observed in the heart,brain,and kidney of rabbits killed by intravenous push or continuous infusion at 100 drips per minute with 0.3% and 1% KCl,respectively.Normal rabbits without any treatment killed by bleeding were used as controls.Results Macroscopically,cardiac dilatation and congestion/stasis as well as ischemic and hypoxic changes in various organs were observed in rabbits died of potassium injection.Microscopically and ultrastructurally,there were destruction of the cardiac fibers with thickening,concentrating,or disappearing of the Z-line,constriction of the glomerular capillaries,enlargement of the Bowman capsule,thinning and fusion of foot processes,as well as apoptosis with phagocytosis in brain observed,particularly in the group infused with 1% KCl.Conclusion The morphologic changes observed in the heart and kidney appear to be characteristic,supporting death caused by potassium intoxication.

Key words: potassium intoxication, ultra-structure, morphological change