法医学杂志 ›› 2014, Vol. 30 ›› Issue (3): 178-180.DOI: 10.3969/j.issn.1004-5619.2014.03.005

• 论著 • 上一篇    下一篇

大鼠甲醇中毒后视网膜电图振荡电位的变化

刘冬梅1,2,周  姝2,3,陈捷敏2,彭书雅1,2,夏文涛2   

  1. (1. 苏州大学医学部法医学系,江苏 苏州 215123; 2. 司法部司法鉴定科学技术研究所 上海市法医学重点实验室,上海 200063; 3. 复旦大学上海医学院法医学系,上海 200032)
  • 发布日期:2014-06-25 出版日期:2014-06-28
  • 通讯作者: 陈捷敏,女,主检法医师,主要从事法医临床学与法医毒理学研究;E-mail:chenjm@ssfjd.cn 夏文涛,男,研究员,主任法医师,硕士研究生导师,主要从事法医临床学的鉴定与研究;E-mail:xiawt@ssfjd.cn
  • 作者简介:刘冬梅(1987—),女,河南商丘人,硕士研究生,主要从事法医临床学研究;E-mail:soochowldm@gmail.com
  • 基金资助:

    上海市法医学重点实验室资助项目(14DZ2270800)

Changes of Oscillatory Potentials of Electroretinogram after Methanol Intoxication in Rats

LIU DONG-MEI1,2, ZHOU SHU2,3, CHEN JIE-MIN2, PENG SHU-YA1,2, XIA WEN-TAO2   

  1. (1. Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, China; 2. Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R. China, Shanghai 200063, China; 3. Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China)
  • Online:2014-06-25 Published:2014-06-28

摘要: 目的 研究大鼠甲醇中毒后视网膜电图(electroretinogram,ERG)振荡电位(oscillatory potentials,OPs)的变化特点。 方法 建立对照组及甲醇中毒3 d组、中毒7 d组的SD大鼠模型,在相应时间点于暗室内进行ERG检测,记录OPs波形特点。 结果 相对于对照组,中毒3 d组和中毒7 d组的总振幅均下降了约50%,时程分别延长约16%和61%。 结论 大鼠甲醇中毒后,ERG的OPs呈现时程延长、总振幅下降特点。

关键词: 法医学, 中毒, 甲醇, 视网膜电图, 振荡电位, 大鼠

Abstract: Objective To study the characters of oscillatory potentials (OPs) of electroretinogram (ERG) after methanol intoxication in rats. Method The SD rat models of methanol intoxication were established and divided into control group, 3-day intoxication group, 7-day intoxication group. The changes of OPs of ERG were recorded in a dark room. Results The total amplitudes of 3-day and 7-day intoxication groups decreased approximately 50% compared with that of the control group, while the schedule delayed approximately 16% and 61%, respectively. Conclusion The characters of methanol intoxication in rats included delay in schedule and decline in the total amplitude of OPs.

Key words: forensic medicine, poisoning, methanol, electroretinogram, oscillatory potentials, rats

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