法医学杂志

法医学杂志 ›› 1987, Vol. 0 ›› Issue (3): 23-26+3.

• 论文 • 上一篇    下一篇

吡啶斯的明的遗传毒理学研究

洪贤慷;薛京伦;邱信芳;殷学军;   

  1. 司法部司法鉴定科学技术研究所,复旦大学遗传学研究所,复旦大学遗传学研究所,复旦大学遗传学研究所,
  • 发布日期:1987-06-25 出版日期:1987-06-28

The Genotoxicity Testing of Mestinon Using Sister Chromatid Exchange as an Indicator

HONG XIANKANG ET AL   

  • Online:1987-06-25 Published:1987-06-28

摘要： <正> 对于人体损伤的鉴定研究工作,以往都集中于机械性损伤,随着社会和科学的发展,由于其它原因引起或造成人体损伤的情况也越来越多,例如环境中的化学因子通过缓慢和长期的作用,能给人体造成不同程度的伤害,特别是某些化合物能诱导人的遗传物质产生突变或畸变,从而使人体受到极其严重的危害。虽然讫今为止尚末见到用类似

Abstract: In the present paper, Mestinon was tested for its possible genotoxicity by using sister chromatid exchange (SCE) as an indicator in human lymphocytes and cultured hamster Wg3-h cells. Experinental results indicated that the SCE frequency in human lymphocytes was incresed by Mestinon which is statistically significant(P 0.01 T test)at a dosage of 500μg/ml. The SCE rates of Wg3-h cells was also increased when Mestinon was actived by S-9 (The rat liver microsome preparation). The differences between the experimental data and the control were signifcant(P 0.001, T test).