法医学杂志

法医学杂志 ›› 1991, Vol. 0 ›› Issue (2): 9-11.

• 论文 • 上一篇    下一篇

上海地区中国人红细胞GPT表型频率调查

吴文庆;陈磊;张其英;   

  1. 上海医科大学法医学教研室,上海医科大学法医学教研室,上海医科大学法医学教研室,
  • 发布日期:1991-04-25 出版日期:1991-04-28

Investigation on the frequencies of the Red Cell GPT Phenotypes in Shanghai district

WU WEN QING CHEN LEI ZHANG QI YING   

  • Online:1991-04-25 Published:1991-04-28

摘要： <正> 谷丙转氨酶(Glutamic—PyruvicTransminas,GPT)是参于机体氨基酸代谢的一类酶,广泛存在于机体各组织中。GPT 有两种形式,一种为线粒体型 GPT(m-GPT),存在于线粒体中,另一种为可溶

Abstract: Genetic polymophism of Soluble glutamic-pyruvic fransminase(GPT)was discoverd by Chen and Gib- lett with Starch-gel electrophoresis of human red cells.Three Common phenotypes,designated GPT_1.GPT_(2-1) and GPT_2,were identified and each was thought to be the expression of two alleles Gpt~1 and Gpt~2 at autosomal locus. In this study we have investigated the polymor-phism of GPT in 235 normal unrelated donors living in Shanghai.Enzyme typing was carried out for Starchgel and specific enzyme Staing.The gene frequen- cies of Gpt~1 and Gpt~2 were estimated at 0.5404 and 0.4596.The observed numbers of the phenotypes were in good agreement with the numbers expected under the Hardy-Weinberg equelihrium(x~2=1.9939 0.1