法医学杂志

法医学杂志 ›› 1992, Vol. 0 ›› Issue (3): 127-130+.

• 论文 • 上一篇    下一篇

海鸥洗净剂灌肠的法毒理学研究

卜俊;颜零;沈彦;   

  1. 司法部司法鉴定科学技术研究所,司法部司法鉴定科学技术研究所,司法部司法鉴定科学技术研究所 上海 200063,上海 200063,上海 200063
  • 发布日期:1992-06-25 出版日期:1992-06-28

FORENSIC TOXICOLOGY OBSERYATION ON THE SEAGEL DETERGENT INCASE OF ENEMA

BU JUN, YAN LING, SHEN YAN   

  • Online:1992-06-25 Published:1992-06-28

摘要： 本文以海鸥洗净剂为例,运用移动平均内插法,分别计算其灌肠和灌胃的LD_(50)。实验结果,其灌肠LD_(50)为0.67g/kg,参照大鼠一次经口毒性分级标准,属中等毒性,明显大于灌胃毒性(LD_(50)=7.33g/kg)。实验证实,碱性环境使洗净剂的毒性增强,酸性环境则无甚影响。综合文献,对洗净剂中的主要成分——表面活性剂的毒性及毒理机制进行了探讨。

关键词: 洗净剂, 灌肠法, 半数致死量

Abstract: We have several death cases of misuse detergent as a lubricant of rectum which was accused as malpractsine The detergent, in which the main component is alkylbenzene sulfonate(ABS), is now recognized as a medium toxic substance. But it is unknown whether the toxicity of detergent, when used as an enema According to the results obtained, because the toxicity is much more severe in basic situation than in acidic situation, the toxicity of seagull Detergent is much more intense in rectum than in stomach. The enema LD50 is 0.67g/kg as a medium toxic substance. So, this would he the reason of death causation when detergent be used as an enema.