法医学杂志

法医学杂志 ›› 1996, Vol. 0 ›› Issue (4): 0-0.

• 论文 •    

婴幼儿猝死综合征心传导系统的免疫组化研究

胡西杰，陈玉川，祝家镇   

  1. 中山医科大学法医病理学教研室
  • 发布日期:1996-08-25 出版日期:1996-08-28

Immunohistochemical Study of the Nervous Tissues of the Cardiac Conduction System in the Sudden Infant Death Sydrome(SIDS)

HU BINGJIE ET.AL.(DEPARTMENT OF FORENSIC PATHOLOGY SUNYAT-SEN UNIVERSITY OF MEDICAL SCIENCES; GUANGDONG510089)   

  • Online:1996-08-25 Published:1996-08-28

摘要： 作者应用ＰＧＰ９．５与抗Ｓ１００抗体和高压消毒蒸锅抗原复活技术对４例婴幼儿猝死综合征（ＳＩＤＳ）和３例非心源性死亡对照婴儿心传导系统的神经组织总量进行免疫组化研究。结果：在正常婴儿心传导系统，ＰＧＰ９．５与Ｓ１００阳性的神经纤维里不均匀分布，以窦房结最多，房室结次之，希氏束最少；４例ＳＩＤＳ心传导系统的神经组织分布同对照组无明显差异。

关键词: 婴幼儿猝死, 心传导系统, 免疫组化

Abstract: In the preset study the general innervation of the cardiac conduction system(CCS) from four sudden infant death sydrome(SIDS) cases and three age-matched controls was investigated.This was achieved by the conbination of specific S100 and PGP 9.5 atibodies,indirect immunoenzymatic technique and autoclave pretrement for antigen retrieval.The results showed that in the three control cases,the general innervation was not uniform throughout the CCS,the rank order being sino-atrial node(S AN)>atrio-ventricular node(AVN)>bundle of His(HB). The four SIDS cases displayed the same pattern as the controls.Further detailed studies are required to clarify the possible role of the developmental abnormality of nerve elements associated with the CCS in genesis of SIDS.

Key words: sudden infant death syndrome, cardiac conduction system, nervous tissue, immunohisto-chemistry