法医学杂志

法医学杂志 ›› 1997, Vol. 0 ›› Issue (3): 135-137+.

• 论文 • 上一篇    下一篇

青壮年猝死综合征心传导系统及心肌HHF35免疫组化研究

罗斌,宋一璇,田野,邓平,谢宇晖,毕启明   

  1. 中山医科大学法医学系!广东广州,1510089,中山医科大学法医学系!广东广州,1510089,广少11军区总医院病理科!广东,510010,中山医科大学法医学系!广东广州,1510089,广少11军区总医院病理科!广东,510010,中山医科大学法医学系!广东广州,1510089
  • 发布日期:1997-06-25 出版日期:1997-06-28

Immunohistochemical study on SMDS using antiactin monoclonal antibody

LUO BIN ET AL(DEPARTMENT OF FORENSIC PATHOLOGY ,SUN YAT-SEN UNIVERSITY OF MEDICAL SCIENCES,GUANGZHOU 510089)   

  • Online:1997-06-25 Published:1997-06-28

被引次数

16

摘要： 为了探讨青壮年猝死综合征（SMDS）的死亡原因与心性猝死之间的关系，作者对SMDS、冠心病、非心血管疾病死亡（正常对照）三组共23例心脏标本进行H．E和HHF35免疫组化观察．结果：9例SMDS中，8例心传导系统及心肌细胞出现小灶性HHF35阴性缺染区，而H．E染色未发现明显梗死灶；冠心病组7例均出现不同程度的心肌细胞缺染，呈广泛大面积分布；对照组心肌细胞、心传导系统及血管壁里均匀一致的阳性染色．表明部分SMDS死前已有早期心肌缺血或梗死等病变，其死亡原因应为急性心功能不全而致猝死．

关键词: 青壮年猝死综合征, 心传导系统, HHF35S-P免疫组织化学方法

Abstract: For elucidating the relationship between the causes ofsudden manhood death syndrom(SMDS) andcardiac sudden death, the cardiac conducting System-(CCS) and myocardium of 23 cases including SMDSgroup, coronary heart disease group and normalcontrol groop were studied using anti-actin mono-clonal antibody(HHF35) S-P immunohistochemical method. The results showed that some areas of CCS and myocardium were stained negatively by hhf35 in SMDS group but no infarctiion area can be found with H.E The negative.staining by HHF35can be also observed in all cases of coronary heartdisease group. Ih control group, the CCS andmyocardium stained positively.It indicated that therewer pathological changes such as early ischemia orinfarction of myocardium in SMDS, which relatedclosely to cardiac sudden death.

Key words: SMDS, CCS, HHF35, S-P immunohistochemical method