法医学杂志

法医学杂志 ›› 2001, Vol. 0 ›› Issue (4): 205-206.

• 论文 • 上一篇    下一篇

挤压综合征大鼠血清酶浓度变化的初步研究

刘水平,陈玉川,郭薇,成建定   

  1. 中山医科大学法医病理教研室,中山医科大学法医病理教研室,中山医科大学法医病理教研室,中山医科大学法医病理教研室 广东广州510080 ,广东广州510080 ,广东广州510080 ,广东广州510080
  • 发布日期:2001-08-25 出版日期:2001-08-28

The preliminary study on change of serum enzyme level in crush syndrome rat

LIU SHUI-PING, CHEN YU-CHUAN,GUO WEI,ET AL.(DEPARTMENT OF FORENSIC PATHOLOGY ,SUN YAT-SEN UNIVERSITY OF MEDICAL SCIENCES,GUANGZHOU 510080)   

  • Online:2001-08-25 Published:2001-08-28

被引次数

6

摘要： 目的观察挤压伤大鼠血清肌酸激酶(CK)、肌酸激酶心肌同功酶(CK-MB)浓度的变化,阐明肢体挤压伤大鼠早期是否存在心脏损伤。方法复制挤压伤大鼠动物模型,全自动生化分析仪检测血清CK、CK-MB浓度的变化。结果挤压伤后12h,血清CK、CK-MB浓度显著升高,并持续48h以上。结论肢体挤压伤早期可能有心脏损伤的存在。

关键词: 挤压综合征, 肌酸激酶, 肌酸激酶心肌同功酶

Abstract: Objective To study the changes of serum creatinine kinase(CK) and its cardiac-specific isoenzyme compound(CK-MB) levels in crush injury rats.Methods Crush injury was produced in SD rats,the serum levels of CK and CK-MB were studied by automated biochemical analyzer.Results The levels of plasma CK and CK-MB were much higher in crush injury rats than those of the control group.Conclusions Cardiomyocyte injury may be induced in the early stage of crush injury rats.

Key words: crush syndrome, creatinine kinase, creatinine kinase cardiac-specific isoenzyme compound