法医学杂志

法医学杂志 ›› 2004, Vol. 0 ›› Issue (3): 185-188.

• 论文 • 上一篇    下一篇

甲基安非他命(冰毒)诱导基因表达变化研究进展

杨静,王晔,刘敏   

  1. 四川大学基础医学与法医学院,四川大学基础医学与法医学院,四川大学基础医学与法医学院 四川成都610041 ,四川成都610041 ,四川成都610041
  • 发布日期:2004-06-25 出版日期:2004-06-28

The study developments about changes of methamphetamine-induced genes' transcriptions and translations

YANG JING(WEST CHINA SCHOOL OF PRECLINICAL AND FORENSIC MEDICINE,SICHUAN UNIVERSITY,CHENGDU610041,CHINA)   

  • Online:2004-06-25 Published:2004-06-28

摘要： 甲基安非他命进入机体后,其最根本的变化是引起了成瘾者许多基因转录和表达改变。这些基因包括与神经元损害有关的基因、与日节律有关的基因、与行为异常有关的基因及其它一些无法分类的基因。它们基因转录和表达水平增高或者降低引起了甲基安非他命成瘾者各种临床表现。研究这些基因表达可以为法医学鉴定提供依据。

关键词: 甲基安非他命, Bcl-2基因家族, HSP70基因家族, arc基因, C-fos, 前强啡肽基因, zif/268基因

Abstract: The basic changes are to transform the levels of many genes' transcriptions and translations when methamphetamine is injected into the organism.Those genes enclose four classes:genes intermediating the dam-ages or death of neurons,genes involving circadian rhythms of activity,genes concerning the abnormality of be-haviors and some genes difficult to be classified.The transformations of the transcriptions or translations of these genes cooperate to produce many clinic syndromes of methamphetamine-addictors.Moreover,the study of these genes can provide testimonies to forensic identification.

Key words: methamphetamine, Bcl-2gene family, HSP70gene family, arc gene, C-fos, preprodynorphin gene, zif/268gene