法医学杂志

法医学杂志 ›› 2007, Vol. 0 ›› Issue (4): 244-246+.

• 论文 • 上一篇    下一篇

钾中毒死亡家兔的尸体化学变化

朱新菊;李西元;李开;陈利萍;柯咏;王振原;   

  1. 西安交通大学医学院法医系,宜君县公安局刑警大队,南京医科大学法医学系,西安交通大学医学院法医系,西安交通大学医学院法医系,西安交通大学医学院法医系 陕西西安710061,镇江市公安局刑警支队,江苏镇江212000,陕西宜君727200,江苏南京210029,陕西西安710061,陕西西安710061,陕西西安710061
  • 发布日期:2007-08-25 出版日期:2007-08-28

Corpus of Biochemical Changes after Death by Potassium Intoxication in Rabbits

ZHU XIN-JU1,2,LI XI-YUAN3,LI KAI4,CHEN LI-PING1,KE YONG1,WANG ZHEN-YUAN1(1.FORENSIC MEDICINE DEPARTMENT,MEDICAL SCHOOL OF XI'AN JIAOTONG UNIVERSITY,XI'AN 710061,CHINA;2.ZHENJIANG PUBLIC SECURITY BUREAU,ZHENJIANG 212000,CHINA;3.YIJUN PUBLIC SECURITY BUREAU   

  • Online:2007-08-25 Published:2007-08-28

摘要： 目的研究家兔钾中毒死亡后的尸体化学变化特征,为钾中毒的法医学鉴定提供参考。方法采用浓度为0.3%和1%的KCl葡萄糖溶液分别以全速和100滴/min的速度输给家兔,至其死亡,测定家兔输液前后血、尿电解质浓度,比较两种不同输液方式所致钾中毒死亡后尸体化学变化特征。结果输钾前后,家兔血清K+(SK)浓度升高,血清Na+、Ca2+、Cl-及HCO3-浓度均降低,全血K+(TK)及血清Mg2+浓度变化无显著性差异。0.3%KCl组致死输液时间长于1%组(P=0.006),致死输钾量无显著性差异(P=0.062);TK、血清Na+、Mg2+及Cl-浓度变化值具有显著差异,SK、Ca2+、HCO3-浓度变化值无显著差异;尿量和尿液各电解质浓度指标未见显著性差异。结论尸体SK、TK及血清Mg2+浓度升高,有助于钾中毒的法医学死后诊断。

关键词: 钾中毒, 死后诊断, 尸体化学

Abstract: Objective To explore the objective evidence of the corpus biochemical changes in rabbits for postmortem diagnosis of potassium intoxication.Methods Rabbits were sacrificed by Infusion of 0.3% KCl at full speed push or 1% KCl at 100 drip/min,respectively,with normal rabbits used as control.Cardiac blood and urine samples were collected before and after potassium infusion to examine the concentrations of various electrolytes(K+,Na+,Ca2+,Mg2+,Cl-,and HCO3-) and to observe the antemortem and postmortem biochemical changes.Results The mean lethal infusion time in the 0.3%KCl group was longer than that in the 1% KCl group(P=0.006).The serum concentration of K+ increased while the serum concentrations of Na+,Ca2+,Cl-,and HCO3-decreased after the infusion.There were no statistically significant differences in the whole blood concentration of K+ as well as the serum concentration of Mg2+ between the two groups(P=0.062).There were statistically significant differences in the concentrations of whole blood K+,as well as serum Na+,Mg2+,and Cl-,but not in the serum K+,Ca2+,and HCO3-.There were no statistically significant differences seen in the urine volumes and the concentrations of all the urine electrolytes between the groups.Conclusion Examination of the concentrations of K+ both in the whole blood and serum,as well as Mg2+ in the serum may be helpful for postmortem diagnosis of potassium intoxication.

Key words: potassium intoxication, postmortem diagnosis, postmortem chemistry