法医学杂志

法医学杂志 ›› 1988, Vol. 0 ›› Issue (2): 26-28.

• 论文 • 上一篇    下一篇

洋金花的法医毒理学研究 Ⅱ、急性毒性的测定

赵台安;郑钟璇;卜俊;沈彦;   

  1. 司法部司法鉴定科学技术研究所,司法部司法鉴定科学技术研究所,司法部司法鉴定科学技术研究所,司法部司法鉴定科学技术研究所,
  • 发布日期:1988-04-25 出版日期:1988-04-28

Forensic-Toxicological Studies on Chinese Crude Drug Yang-Jin-Hua (Datura) Ⅱ. An Investigation on Acute Toxicity

ZHAO TAIAN;ZHENG ZHONGXUAN;BU JUN;SHEN YAN INSTITUTE OF FORENSIC SCIENCES, MINISTRY OF JUSTICE. PRC   

  • Online:1988-04-25 Published:1988-04-28

摘要： <正> 洋金花(曼陀罗)是常用的中草药,在临床上用于麻醉,治疗慢性气管炎和精神分裂症等症。洋金花又是有毒的植物,关于其中毒乃至误食致死的报道屡见于文献。“其花、叶、果实、种子均能使人中毒,中毒的时间一般以深秋(九、十月份)为多,以果实和种子中毒为主。”洋金花的有毒成份主要是生物碱。包括阿托品、莨菪碱和东莨菪碱。根据《全国中草药汇编》报道,“曼陀

Abstract: There are some data on acute toxity of Yang-Jin·Hua (Datura), but they are Very rough and ambigurous. In this paper, an acute toxity of Yang-Jin- Huan was reported. Exstracts from its flower, fruit and seed were experimen- ed on 180 rats. The results showed fhat the LD50 of exstracts from flower. fruit and seed were 14. 9314, 7. 7625 and 7. 1746 g/kg respectively, The toxici- ty of Yang-Jin-Hua was very high and the toxity of its flower was lower than that of its fruit and seed. The alkaloids in flower, though it was a little strange, were much more than that in fruit and seed. The reason of it was not clear.