法医学杂志 ›› 1989, Vol. 0 ›› Issue (3): 5-8+2.

• 论文 • 上一篇    下一篇

喹啉类药物中毒的病理变化—动物实验研究

张武扬;沈念慈;何德华;董荣春;詹镕洲;   

  1. 第二军医大学,第二军医大学,第二军医大学,第二军医大学,第二军医大学,
  • 发布日期:1989-06-25 出版日期:1989-06-28

The Pathological Changes of Quinolines Poisoning: An Experimental Study

ZHANG WUYANG, SHEN NIANCI, HE DEHUA, DONG RONGCHUN AND ZHAN RONGZHOU(SECOND MILITARY MEDICAL GOLLEGE, SHANGHAI)   

  • Online:1989-06-25 Published:1989-06-28

摘要: <正> 喹啉类药物是常用的抗疟药,都是奎宁的衍生物,主要有8—氨基喹啉类和4—氨基喹啉类。近年还用喹啉类药物治疗阿米巴病、肺吸虫病、华支睾吸虫病、类风湿性关节炎、红斑性狼疮、心律失常、硅肺和癌症等,由于治疗的疗程长,总剂量大,中毒的可能性增加。过去曾报道使用啉喹类药物后发生心脏传导阻滞、阿一斯氏综合征、溶血性贫血、中枢神经和视网膜损害等,严

Abstract: The histological and ultrastructural features of the laboratory animals ncluding dogs, monkeys and rats were observed in the experiments of quinolines poisoning. The morphological alterations in the myocardium and conduction systems were the important pathological changes in the intoxicated dogs. The changes in the liver were mild and reversible.Some ntoxieated rats revealed severe adrenal lesions.