法医学杂志

法医学杂志 ›› 1989, Vol. 0 ›› Issue (3): 9-11+8.

• 论文 • 上一篇    下一篇

急性犬心肌缺血后冠脉再灌注损伤 Ⅰ、心肌梗塞范围的研究

官大威;李德祥;朱宝利;   

  1. 中国医科大学法医学系法医病理学教研室,中国医科大学法医学系法医病理学教研室,中国医科大学法医学系法医病理学教研室,
  • 发布日期:1989-06-25 出版日期:1989-06-28

Reperfusion Injury to Acute Post-ischemic Myocardium in Dogs Ⅰ. Effect of reperfusion on infarct size

GUAN DANWEI LI DENXIANG JU BAOLI(DEPARTMENT OF FORENSIC PATHOLOGY, FACULTY OF FORENSIC MEDICINE, CHINA MEDICAL UNIVERSITY)   

  • Online:1989-06-25 Published:1989-06-28

摘要： <正> 冠状动脉粥样硬化性心脏病不仅在临床心血管疾病的死亡率中占首位,而且也是法医病理学鉴定中最常见的心脏性猝死原因。现代医学发展使临床上对早期心肌梗塞的患者可以实施冠脉溶血栓疗法,或冠脉搭桥术,使阻塞的冠状动脉再通,即冠脉再灌注,以期促进缺血心肌的恢复。虽然国外许多学者对冠脉再灌注的效果已有研究,但结果并不一致。一些实验结果表明早期心肌缺血后冠脉再灌注120分钟使缺血心肌

Abstract: The present experiment was performed to study the effect of postischemic reperfusion on infarct size in dogs. The results showed that no necrotic area was revealed on the sliced myocardium incubated with NBT in the group of coronary occlusion for 60 min. The infarct size expres sed as a percentage of the left ventricular and septal mass (g) was 0±0%(Mean SE). After post-isehemie reperfusion, the value was 11.05±4.28％ (P<0.01). In the group of coronary occlusion for 90 min, the percentage was 17.96±2.85％, and it was 21.41±1.86％ (P<0.05) followed by reperfusion for 120 min.In conclusion,early reperfusion causes enlarged infarct size and exacerbates the pre-existing ischemic myocardial injury.