法医学杂志

法医学杂志 ›› 1996, Vol. 0 ›› Issue (1): 0-0.

• 论文 •    

青壮年猝死综合征心肌细胞内纤维连接蛋白免疫组化观察初探

胡丙杰，陈玉川，祝家镇   

  1. 中山医科大学法医学系
  • 发布日期:1996-02-25 出版日期:1996-02-28

Immunohistochemical Demonstration of Fibronectin in Myocytes of Sudden Manhood Death Syndrome

HA BINGJIE; CHEN YACHUAN;ZHU JINZHEN (DEPARTMENT OF FORENSIC PATHOLOGY,SUN YAT-SEN UNIVERSITY OF MEDICAL SCIENCES;GUANGDONG 510089)   

  • Online:1996-02-25 Published:1996-02-28

被引次数

24

摘要： 本文应用免疫组化ＬＳＡＢ法首次对５例青壮年碎死综合征和１１例非心性死亡对照组进行心肌细胞内纤维连接蛋白的研究。发现青壮年猝死综合征５例中有３例心肌细胞内纤维连接蛋白阳性。１１例非心性死、对照组心肌细胞内纤维连接蛋白均呈阴性。说明上述３例青壮年猝死综合征的心肌细胞已发生不可逆损伤，实属早期心肌梗死。该研究为青壮年猝死综合征的死因研究提供了一个新的方向和手段。

关键词: 青壮年猝死综合征, 纤维连接蛋白, 免疫组化, LSAB法

Abstract: Immunohistochemical study of fibronectin (FN) was performed on the hearts of o cases of sudden manhood death syndromc (SMDS) and 11 cases of noncardiac death controls with LSAB-method. The results showed that FN was positive in cardiomyocytes of 3 cases of SMDS, but negative in all 11 non-cardiac death controls.It indicated that irreversible cell injury bad taken place in the 3 cases of SMDS,which.should be diagnosed as early myocardial infarction.This experiment provides a new approach for studying the causes of death of SMDS.

Key words: sudden manhood death syndrome, fibronectin, immunohistochemistry, LSAB-method