法医学杂志

法医学杂志 ›› 1996, Vol. 0 ›› Issue (3): 0-0.

• 论文 •    

全血中度冷丁的气-联用法测定及代谢动力学的研究

薛月华，沈敏，沈保华，向平，吴侔天   

  1. 上海第一人民医院护士学校，上海司法部司法鉴定科学技术研究所
  • 发布日期:1996-06-25 出版日期:1996-06-28

The Determination of Meperdine in Human Blood by GC/MS and its Pharmacokinetic Study

XUE YUEHUA (SHANGHAI FIRST HOSPITAL) SHEN MIN.SHEN BAOHUA XIANG PING AND WU MOUTIAN (INSTITUTE OF FORENSIC .SCIENCES.MINISIRY OF JUSTICE. SHANGHAI, 200064)   

  • Online:1996-06-25 Published:1996-06-28

摘要： 应用气－质联用选择离子法测定全血中度冷丁的浓度。方法线性范围为０．００２～１ｎｇ／ｍｌ（ｒ＝０．９９９７），变异系数小于１０％，最低检测限过１ｎｇ／ｍｌ，无杂质干扰。本法已用于肌注８０ｍｇ度冷丁后代谢动力学的研究。

关键词: 气－质联用, 选择离子法, 度冷丁, 代谢动力学

Abstract: A GC/MS assay using selected ion monitering for meperdine in blood is described. Caliblation curve is linear over 0.002 to 1.0μg/mL.(r=0.9997). the results reproducible (CV＜10%).the sensitivity limit is about 1ng/mL and no interference is present in blank blood. The method has been applied to pharmacokinetic studies after intramuscular injection of 80 mg meperdine.

Key words: GC/MS: meperdine, pharmacokinetic.