法医学杂志

法医学杂志 ›› 1999, Vol. 0 ›› Issue (2): 0-0.

• 论文 •    

病毒性心肌炎肌动蛋白的免疫组化观察

成建定,陈玉川,胡丙杰   

  1. 中山医科大学法医病理学教研室
  • 发布日期:1999-04-25 出版日期:1999-04-28

Immunohistochemical observation of actin in viral myocarditis

CHENG JIANDING, CHEN YUCHUAN, HU BINGJIE (DEPARTMENT OF FORENSIC PATHOLOGY, SUN YAT-SEN UNIVERSITY OF MEDICAL SCIENCES, GUANGZHOU 510089, P.R.CHINA)   

  • Online:1999-04-25 Published:1999-04-28

被引次数

6

摘要： 对１０例尸检心脏标本进行了肌动蛋白（Ａｃｔｉｎ，Ａｔ）的免疫组化观察。依据Ｄａｌｓ标准的明确或界限性病毒性心肌炎５例，心肌组织内Ａｔ含量减损，呈局灶性或弥漫性淡染，偶见小灶性单个心肌细胞内Ａｔ缺失。心肌梗死２例，心肌组织内Ａｔ大片缺失；非心性死亡对照组３例，心肌组织内Ａｔ呈均匀一致的强阳性染色。结果表明，心肌组织内Ａｔ的免疫组化观察可望提高对不典型病毒性心肌炎诊断的敏感性，同时对区分轻度缺血性与炎症性心肌细胞损伤有参考价值

关键词: 病毒性心肌炎, 肌动蛋白, 免疫组化

Abstract: 10 specimens of heart in autopsy were immunohistochemically studied by using anti-actin(At) antibody. In 5 cases with definite or suspected viral myocarditis according to Dallas criteria, actin in myocardium showed focal or diffuse weak staining, and occasionally showed focal absence of staining. In 2 cases with myocardial infarction, actin showed large pieces absent of staining, while actin in 3 cases with non-cardiac death showed strongly positive, well-distributed staining. The results indicated the immunohistochemical observation of actin in myocardium is useful for improving the sensitivity in diagnosing viral myocarditis and differentiating the slight injuries of myocytes caused by ischemia or inflammation.

Key words: viral myocarditis, actin, immunohistochemistry