法医学杂志

法医学杂志 ›› 1997, Vol. 0 ›› Issue (1): 14-15+6.

• 论文 • 上一篇    下一篇

氯氮平在家兔体内的分布研究

员克明,李贵明   

  1. 山西医科大学法医学系!山西,太原,030001,山西医科大学法医学系!山西,太原,030001
  • 发布日期:1997-02-25 出版日期:1997-02-28

Study on distribution of alprazolam in poisoned rabbits

YUN KEMING; LI GUIMING .(DEPARTMENT OF FOSRENSIC MEDICINE, SHANXI MEDICAL UNIVERSITY; SHANXI 030001)   

  • Online:1997-02-25 Published:1997-02-28

被引次数

20

摘要： 本文用薄层色谱扫描法研究了氯氮平在染毒家兔体内的分布情况，以639mg／kg剂量给家兔灌胃使其染毒致死．检验结果表明，其体内血、尿、胆汁、肝、脾、肾、心、肺和脑内氯氮平的浓度分别为19．1±6．9、50．2±12．6、75．9±12．5、25．9±4．0、34．0±47、13．3±2．2、5．0±2．3、20．0±4．3和43．6±43．4μg／g或μg／ml．

关键词: 氯氮平, 中毒, 体内分布, 薄层色谱

Abstract: The distribution of clozapinc in the body of rabbits died of poison was studied by the method of TLC.The concentration of clozapine in blood. urine,bile,livers. kidneys. spleen. lungs.hearts and brainse were19.4±6.9, 50.2±12.6,75.9±12.5,25.9±4.0,34.0±4.7,13.3±2.2, 20.0±4.3, 5.0±2.3 and 43.6±43, 4ug/ml or ug/g.respectively. It is concluded that the Clozapine be not well-distribuled in poisoned rabbits. Blood. bile,urine.liver and spleen are better samples for the analysis of clozapine than others.

Key words: Clozapine, TLC, Poisoning, Distribution