法医学杂志

法医学杂志 ›› 2002, Vol. 0 ›› Issue (2): 76-77.

• 论文 • 上一篇    下一篇

肢体挤压伤大鼠早期心电图及血清cTnI的变化

陈玉川,刘水平,郭薇   

  1. 中山医科大学法医病理学教研室,中山医科大学法医病理学教研室,中山医科大学法医病理学教研室 广东广州510080 ,广东广州510080 ,广东广州510080
  • 发布日期:2002-04-25 出版日期:2002-04-28

The changes of electrocardiogram and serum cardiac troponin I at the early stage of crush injury in rats

CHEN YU-CHUAN,LIU SHUI-PING,GUO WEIDEPARTMENT OF FORENSIC PATHOLOGY,SUN YAT-SEN UNIVERSITY OF MEDICAL SCIENCES,GUANGZHOU510080   

  • Online:2002-04-25 Published:2002-04-28

被引次数

2

摘要： 目的观察挤压伤大鼠早期心电图的改变,并检测血清心肌肌钙蛋白I(cTnI)的变化。方法复制挤压伤大鼠动物模型,标准Ⅱ导联记录心电图变化,化学发光法检测血清cTnI水平。结果挤压伤后心电图ST段明显抬高,并持续24h,伤后6h血清cTnI则显著升高,并持续24h以上。结论肢体挤压伤早期存在心肌细胞的损伤。

关键词: 挤压损伤, 心肌肌钙蛋白, 心电图

Abstract: Objective To observe the changes of electrocardiogram and serum cardiac troponin I at the early stage of severe crush injury in rats.Methods Crush injury was produced in Sprague-Dawley rats.The changes of electrocardiogram were recorded with the standard Ⅱ ,the serum levels of cardiac troponin I were studied by automated chemiluminescence assay.Results The ST segment elevated considerably after crush injury and lasted24h,the levels of serum cTnI were much higher than those of the control groupes after6h of injury.Conclusion Cardiomyocyte injury was induced in the early phase of crush injury.

Key words: crush, injury, cardiac troponin, electrocardiogram.