法医学杂志

法医学杂志 ›› 2008, Vol. 24 ›› Issue (3): 214-220.

• 论文 • 上一篇    下一篇

亲权鉴定中常用STR基因座的基因组学和遗传学分析

李成涛;郭宏;赵珍敏;李莉;   

  1. 司法部司法鉴定科学技术研究所上海市法医学重点实验室,苏州大学基础医学院,司法部司法鉴定科学技术研究所上海市法医学重点实验室,司法部司法鉴定科学技术研究所上海市法医学重点实验室 上海200063,复旦大学生命科学学院,上海200433,苏州215123,上海200063,上海200063
  • 发布日期:2008-06-25 出版日期:2008-06-28

Analysis of Genetics and Genomics of Short Tandem Repeat Loci Commonly Used in Kinship Testing

LI CHENG-TAO1,2, GUO HONG3, ZHAO ZHEN-MIN1, LI LI1 (1. SHANGHAI KEY LABORATORY OF FORENSIC MEDICINE, INSTITUTE OF FORENSIC SCIENCE, MINISTRY OF JUSTICE, P.R.CHINA, SHANGHAI 200063, CHINA; 2. SCHOOL OF LIFE SCIENCES, FUDAN UNIVERSITY, SHANGHAI 200433, CHIN   

  • Online:2008-06-25 Published:2008-06-28

被引次数

44

摘要： 美国联邦调查局建立的联合DNA索引系统即CODIS系统至今已有10年,该系统确定的13个STR基因座及近年来开发的PentaD、PentaE、D2S1338和D19S433基因座被全世界范围内的实验室广泛采用,在亲权鉴定和罪犯数据库建设等方面发挥了重要的作用。本文利用Web of Knowledge核心检索系统和Elsevier等全文数据库及网络资源,对近年来常用STR基因座的基因组学特征和遗传学特征进行了深入地分析,并对这些STR基因座在实践中的应用情况进行了综述。

关键词: 法医生物学, 基因组学, STR, 基因座, 联合DNA索引系统

Abstract: Since the foundation of FBI laboratory′s Combined DNA Index System (CODIS) a decade ago, the 13 CODIS STR loci of the system as well as the recently developed Penta D, Penta E, D2S1338 and D19S433 loci have been widely used by kinship testing laboratories worldwide and have played an important role in the field of Kinship Testing and in construction of criminal database. This article systemically analyzed the characteristics of STR loci information and its genomic information analyzed through search of a variety of database including Web of Knowledge, Elsevier and Internet resources. The up-to-date application of the commonly used STR loci in recent years is also reviewed.

Key words: forensic biology, genomics, combined DNA index system, STR loci