法医学杂志

法医学杂志 ›› 2008, Vol. 0 ›› Issue (6): 453-456.

• 论文 • 上一篇    下一篇

NF-κB与神经系统损害的研究进展

张运阁;陶陆阳;   

  1. 苏州大学医学部法医学系;
  • 发布日期:2008-12-25 出版日期:2008-12-28

Recent Advances of NF-κB in Nervous System Injury

ZHANG YUN-GE, TAO LU-YANG (DEPARTMENT OF FORENSIC MEDICINE, MEDICAL COLLEGE, SOOCHOW UNIVERSITY, SUZHOU 215123, CHINA)   

  • Online:2008-12-25 Published:2008-12-28

摘要： 神经系统损害在法医学鉴定实践中较为常见,同时也是法医学鉴定的难点之一。近年来,国内外学者试图通过核转录因子-κB(nuclear factor-kappa B,NF-κB)的激活情况来为神经系统损害程度的法医学鉴定提供客观依据,并研究在神经系统损伤后NF-κB表达的时间变化规律,为法医学损伤时间推断提供新的客观指标。本文综述了脑缺血、脑外伤、阿尔茨海默病、肌萎缩侧索硬化病等一系列神经系统损害与NF-κB激活的关系、研究进展以及尚需解决的问题。

关键词: 法医学, NF-κB, 综述[文献类型], 创伤, 神经系统, 神经系统疾病

Abstract: Diagnosis of nervous system injury is one of the most difficult issues in medical-legal practice. Nowadays, the activation of NF-κB has been studied by many researchers in order to find objective evidence and indicators to calculate the injury time and to diagnose the severity of brain injury for forensic practice. It was reviewed that the advances and problems of NF-κB and its correlation with nervous system injury and diseases, such as cerebral ischemia, traumatic brain injury, Alzheimer′s disease and amyotrophic lateral sclerosis.

Key words: forensic medicine, NF-kappa B, review [publication type], trauma, nervous system, nervous system diseases