法医学杂志

法医学杂志 ›› 2009, Vol. 0 ›› Issue (1): 19-23.

• 论文 • 上一篇    下一篇

脑损伤患者听觉P300电位特点

崔勇;刘帆;张馨元;汤鹏;刘鹏;张彪;刘技辉;   

  1. 中国医科大学法医学院临床法医学教研室;辽宁中医药大学基础医学院;中国医科大学;
  • 发布日期:2009-02-25 出版日期:2009-02-28

Auditory P300 in the Patients with Traumatic Brain Injury

CUI YONG1,2, LIU FAN3, ZHANG XIN-YUAN1, TANG PENG1, LIU PENG1, ZHANG BIAO1, LIU JI-HUI1 (1. DEPARTMENT OF CLINICAL FORENSIC MEDICINE, SCHOOL OF FORENSIC MEDICINE, CHINA MEDICAL UNIVERSITY, SHENYANG 110001, CHINA; 2. COLLEGE OF BASIC MEDICAL SCIENCE, LIAON   

  • Online:2009-02-25 Published:2009-02-28

摘要： 目的探讨听觉P300电位对脑损伤患者认知功能障碍程度法医学评价的应用价值。方法对正常人和脑损伤患者,分别在主动(踩踏板)与被动任务状态下进行听觉P300测试。结果正常人主动任务状态P300电位中的N2、P3波波幅较被动状态高,潜伏期无明显延长,N1、P2波幅Cz点高于Pz点。脑损伤组被动任务状态下N2、P3波波幅较正常人被动状态下高,且潜伏期延长。脑损伤组主动任务状态P300电位中的N2、P3波波幅较被动状态高,且潜伏期延长。注意障碍患者P3波潜伏期改变最明显。结论任务类型主要影响N2、P3波幅。被动反应中的N2、P3潜伏期可作为评价脑损伤患者认知功能的指标。

关键词: 法医学, 事件相关电位, P300, 脑损伤, 认知

Abstract: Objective To assess the cognitive dysfunction in patients with the traumatic brain injury(TBI) by auditory P300. Methods Auditory P300 was recorded in the normal subjects and patients with TBI at the active(foot pedal) and passive task. Results In healthy persons, N2 and P3 in active task state showed higher amplitude than that in passive task state, and no significant prolongation of the latency. The ampli- tude of N1 and P2 at Cz was higher than that at Pz. In passive task state, N2 and P3 showed higher amplitude and longer latency in the patients than that in the healthy persons. N2 and P3 of the patients in the active task showed higher amplitude and longer latency than that in the passive task. Obvious change of P3 latency was observed in the patients with attention disorder. Conclusion The type of task mainly affect the amplitude of N2 and P3. The latency of N2 and P3 in passive task can be used as an indication for evaluating cognitive function in patients with diffuse brain injury.

Key words: forensic medicine, event-related potentials, P300, brain injuries, cognition