法医学杂志

法医学杂志 ›› 2009, Vol. 0 ›› Issue (5): 329-331.

• 论文 • 上一篇    下一篇

小鼠急性八角枫中毒的病理学观察

张长银;张礼俊;胡永良;夏显东;卢林明;闫宜锋;徐祥;柯玮;朱建华;   

  1. 池州秋诚司法鉴定所;旌德县公安局;皖南医学院医学三系;皖南医学院病理教研室;
  • 发布日期:2009-10-25 出版日期:2009-10-28

The Pathological Observation of Acute Intoxication by Alangium Chinese in Mice

ZHANG CHANG-YIN1,ZHANG LI-JUN2,HU YONG-LIANG3,XIA XIAN-DONG3,LU LIN-MING4,YAN YI-FENG3,XU XIANG3,KE WEI3,ZHU JIAN-HUA3(1.CHIZHOU QIUCHENG FORENSIC JUDICAL APPRAISAL INSTITUTE,CHIZHOU 247000,CHINA;2.JINGDE PUBLIC SECU-RITY BUREAU,JINGDE 242600,CHINA;3.THE   

  • Online:2009-10-25 Published:2009-10-28

被引次数

9

摘要： 目的观察急性八角枫中毒小鼠器官组织病理学变化并探讨其中毒机制。方法应用八角枫须根水煎液对小鼠灌胃急性染毒,提取组织器官经HE染色后进行病理学观察。结果实验组主要病理改变为肺泡腔出血、肺间质出血,肝窦扩张、淤血,肝细胞水肿,蛛网膜下腔出血,其他器官呈淤血、出血性改变。结论八角枫毒性作用的主要靶器官或靶组织为肺、肝和血管平滑肌;毒性作用与剂量具有相关性。

关键词: 法医病理学, 中毒, 八角枫, 小鼠

Abstract: Objective To investigate the pathological change of mice organ intoxicated by Alangium Chinese and its poisoning mechanism.Methods Mice were intoxicated by gavage with extract of Alangium Chinese.Then the histopathologic examination was made for evaluating the pathological changes in the organs of the poisoned mice by HE staining.Results The main pathological changes included alveolar hemorrhage,pulmonary interstitial hemorrhage,sinus hepaticus expansion and congestion,hepatocyte edema,subarach-noid hemorrhage,congestion and hemorrhage of other organs.Conclusion The main target organs or tissue of Alangium Chinese are the lungs,liver and vascular smooth muscle.There is correlation between the toxic effect and the dosage.

Key words: forensic pathology, poisoning, Alangium Chinense, mice