法医学杂志

法医学杂志 ›› 2009, Vol. 0 ›› Issue (5): 334-336.

• 论文 • 上一篇    下一篇

病毒性心肌炎猝死心肌MCP-1表达及其法医学意义

宁娟;李永宏;张纯兵;   

  1. 皖南医学院法医病理学教研室;华东政法大学司法鉴定中心;
  • 发布日期:2009-10-25 出版日期:2009-10-28

Expression of Monocyte Chemoattractant Protein-1 in Sudden Death due to Viral Myocarditis and Its Medicolegal Significance

NING JUAN1,2,LI YONG-HONG1,ZHANG CHUN-BING2(1.DEPARTMENT OF FORENSIC PATHOLOGY,WANNAN MEDICAL COLLEGE,WUHU 241001,CHINA;2.FORENSIC EXPERTISE CENTER,EAST CHINA UNIVERSITY OF POLITICAL SCIENCE AND LAW,SHANGHAI 200042,CHINA)   

  • Online:2009-10-25 Published:2009-10-28

被引次数

8

摘要： 目的探讨单核细胞趋化蛋白1(monocyte chemoattractant protein-1,MCP-1)在病毒性心肌炎(viral myocarditis,VMC)所致猝死者心肌组织中的表达及其意义。方法运用改良的免疫组织化学方法,观察VMC猝死组和对照组心肌组织中MCP-1的表达情况,应用统计学处理,比较两组间的表达差异。结果20例VMC猝死组中有17例MCP-1染色阳性;而20例非VMC猝死对照组仅4例局部散在MCP-1弱阳性表达,其余均阴性。VMC组MCP-1阳性表达率明显高于对照组(P<0.01)。结论MCP-1的免疫组织化学检测可作为法医病理学诊断VMC所致猝死较为客观的病理形态学指标之一。

关键词: 法医病理学, 单核细胞化学吸引蛋白质类, 猝死, 心脏, 病毒性心肌炎

Abstract: Objective To explore the expression and significance of monocyte chemoattractant protein-1(MCP-1) in myocardium in sudden death caused by viral myocarditis(VMC).Methods To investigate the expression of MCP-1 in VMC sudden death group and control group using improved immunohistochemical technique and to compare the difference of the expression of MCP-1 between two groups with statistical method.Results In VMC sudden death group,MCP-1 was positively expressed in 17 of 20 cases.While only 4 of the 20 cases in the control group showed a mildly positive expression sparsely in myocardium,and the rest cases were completely negative.The rate of positive expression of MCP-1 in VMC group was obviously higher than that of the control group(P<0.01).Conclusion The expression of MCP-1 detected by immunohistochemistry provides an objective morphologic evidence for the diagnosis of VMC sudden death in forensic pathology.

Key words: forensic pathology, monocyte chemoattractant proteins, death, sudden, cardiac, viral myocarditis