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Sudden Cardiac Death CHENG Jian-ding

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Please wait a minute... For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails Select    2017, 33 (5): 455-456.   DOI: 10.3969/j.issn.1004-5619.2017.05.001 Abstract （752）            Knowledge map    Save Related Articles | Metrics | Comments（0） Select Research Progress of Sudden Cardiac Death in Forensic Medicine ZHENG DA, YIN KUN, ZHENG JING-JING, ET AL.    2017, 33 (5): 457-469.   DOI: 10.3969/j.issn.1004-5619.2017.05.002 Abstract （683）            Knowledge map    Save Sudden death （SD） is a special kind of death owing to disease, which severely threatening the lives of community population. As the most common type of SD, sudden cardiac death （SCD） has always been a crucial content of identification and research in forensic pathology. This article reviews the research progress from the aspects of epidemiology, morphology, molecular pathology and virtual anatomy of SCD in forensic medicine, so as to provide a reference for the morphological identification, determination of cause of death, and integrated control of this kind of SD. Related Articles | Metrics | Comments（0） Select Research Progress of Yunnan Unexplained Sudden Death HE YONG-WANG, ZHAO XIANG-YUE, JIA PENG-LIN, ET AL.    2017, 33 (5): 470-475.   DOI: 10.3969/j.issn.1004-5619.2017.05.003 Abstract （701）            Knowledge map    Save Yunnan unexplained sudden death （YUSD） has obvious spatial and temporal aggregations. With the features of sudden onset and rapid death, its causes remain unclear. However, the onset of YUSD is related to the geological and climatic conditions in specific range of altitude of incidence area, which is also influenced by the existed susceptibility gene loci or several multiple mutations in SNP loci, long-term fatigue, low dietary nutrition, trace element deficiency, poor living condition and hygienic habit, and infection by etiologic microorganism or virus among the residents live in the incidence area of YUSD. Under the continuous influence of factors above, the crowd of incidence area finally occurred unexplained sudden death that prominently shown by myocardial injury. Improvements of public health administration, living conditions, villagers’ health, living habits and enhancement of indicator measurement of myocardial enzyme and electrocardiogram for the residents in the incidence area of YUSD are effective measures for prevention of YUSD. Timely identification of cause of death and in-depth genetic research are important ways to explore the causes of YUSD, enhance the effectiveness of treatment and reduce the death rate. Related Articles | Metrics | Comments（0） Select Expression of proBNP and NT-proBNP in Sudden Death of Coronary Heart Disease ZENG QIANG, SUN RUI-FENG, LI ZE，ET AL.    2017, 33 (5): 476-481.   DOI: 10.3969/j.issn.1004-5619.2017.05.004 Abstract （482）            Knowledge map    Save Objective To study the expression change of pro-brain natriuretic peptide （proBNP） and N-terminal pro-brain natriuretic peptide （NT-proBNP） in sudden death of coronary atherosclerotic heart disease, and to explore its application in forensic diagnosis. Methods Myocardial and blood samples were collected from normal control group, sudden death of coronary atherosclerotic heart disease group and single coronary stenosis group （20 cases in each group）. The expression of proBNP in myocardial samples were detected by immunohistochemical staining and Western blotting, and that of BNP mRNA were detected by reverse transcription PCR （RT-PCR）. The content of NT-proBNP in plasma were detected by ELISA. Results Immunohistochemical staining showed positive expression of proBNP in both sudden death of coronary atherosclerotic heart disease group and single coronary stenosis group. There was no positive expression in normal control group. For sudden death of coronary atherosclerotic heart disease group and single coronary stenosis group, the relative expression of proBNP protein and BNP mRNA in myocardial tissue and the NT-proBNP content in plasma were higher than that of normal control group （P<0.05）. The NT-proBNP content in plasma of sudden death of coronary atherosclerotic heart disease group was higher than that of single coronary stenosis group （P<0.05）. Conclusion In myocardial ischemia condition, the higher expression of proBNP in cardiac muscle cell shows that the detection of NT-proBNP in plasma can be useful to differentially diagnose the degree of coronary atherosclerotic heart disease and determine whether the sudden death due to coronary atherosclerotic heart disease. Related Articles | Metrics | Comments（0） Select Forensic Analysis of 6 Cases of Sudden Death due to Hyperthyroid Heart Disease ZHANG MENG-ZHOU, LI BING-XUAN, ZHAO RUI, ET AL.    2017, 33 (5): 482-485.   DOI: 10.3969/j.issn.1004-5619.2017.05.005 Abstract （474）            Knowledge map    Save Objective To analyse the cases of sudden death due to hyperthyroid heart disease, and explore the general information of deaths and the forensic pathological characteristics to provide reference evidence for forensic identification of such cases. Methods Six cases of sudden death due to hyperthyroid heart disease between 2001 and 2016 were selected from School of Forensic Medicine, China Medical University. The general information （gender and age）, clinical manifestations, medical history, anatomical and histopathological findings, biochemical parameters and cause of death were analysed retrospectively. Results Most of the 6 patients had definite history of hyperthyroidism, and they all showed certain degrees of symptoms of cardiovascular disease; had obvious incentive factors of death; histopathological examination of thyroid conformed to the performances of diffuse toxic goiter; with increase of cardiac weight, dilatation of cardiac chambers, myocardial hypertrophy and focal necrosis; postmortem biochemical analyses of pericardial fluid could be used as an additional method for diagnostic of sudden death due to hyperthyroid heart disease. Conclusion The identification of death due to hyperthyroid heart disease should be based on the clinical history and the results of autopsy, histopathological examination, postmortem toxicology tests. The postmortem biochemical detection of thyroid and cardiac function should be performed if necessary. Related Articles | Metrics | Comments（0） Select    2017, 33 (5): 486-488.   DOI: 10.3969/j.issn.1004-5619.2017.05.006 Abstract （292）            Knowledge map    Save Related Articles | Metrics | Comments（0） Select    2017, 33 (5): 489-490.   DOI: 10.3969/j.issn.1004-5619.2017.05.007 Abstract （383）            Knowledge map    Save Related Articles | Metrics | Comments（0） Select    2017, 33 (5): 491-492.   DOI: 10.3969/j.issn.1004-5619.2017.05.008 Abstract （478）            Knowledge map    Save Related Articles | Metrics | Comments（0）