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Postmortem Examination of COVID-19 WANG Hui-jun

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For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails Select   法医学杂志    2020, 36 (1): 1-3.   DOI: 10.12116/j.issn.1004-5619.2020.01.001 Abstract （479）      PDF（pc） （979KB）（4186）       Knowledge map    Save   Reference | Related Articles | Metrics | Comments（0） Select   法医学杂志    2020, 36 (1): 4-5.   DOI: 10.12116/j.issn.1004-5619.2020.01.002 Abstract （328）      PDF（pc） （930KB）（3454）       Knowledge map    Save   Reference | Related Articles | Metrics | Comments（0） Select Guide to the Forensic Pathology Practice on Death Cases Related to Corona Virus Disease 2019 （COVID-19） （Trial Draft） MAO Dan-mi, ZHOU Nan, ZHENG Da, et al. 法医学杂志    2020, 36 (1): 6-15.   DOI: 10.12116/j.issn.1004-5619.2020.01.003 Abstract （567）      PDF（pc） （1102KB）（3744）       Knowledge map    Save Autopsy is of great significance to the elucidation of the pathological changes, pathogeneses and causes of death of corona virus disease 2019 （COVID-19） and can provide theoretical basis for more scientific and accurate prevention and control of the outbreak. Based on related laws and regulations, such as the Law of the People’s Republic of China on Prevention and Control of Infectious Diseases, the clinical manifestations and epidemiological characteristics of COVID-19, and the related guidelines on the prevention and control of the outbreak, combined with the practical work of forensic pathology examination, the Guide to the Forensic Pathology Practice on Death Cases Related to Corona Virus Disease 2019 （COVID-19） （Trial Draft） has been developed. This guide includes information on the background investigation of the cases, autopsy room requirements, personal prevention and protections, external examinations, autopsy, auxiliary examinations, and so on. This guide can be used as a reference by forensic and pathological examination institutions, as well as examination staff. Reference | Related Articles | Metrics | Comments（0） Select Review and Prospect of Pathological Features of Corona Virus Disease WANG Hui-jun, DU Si-hao, YUE Xia,et al. 法医学杂志    2020, 36 (1): 16-20.   DOI: 10.12116/j.issn.1004-5619.2020.01.004 Abstract （1516）      PDF（pc） （1293KB）（11087）       Knowledge map    Save Since 2003, coronavirus has caused multiple major public health events that resulted in global epidemics, such as severe acute respiratory syndrome （SARS）, Middle East respiratory syndrome （MERS） and corona virus disease 2019 （COVID-19）. Especially since COVID-19 outbroke in Wuhan, Hubei, in December 2019, coronavirus has had a significant impact on people’s health and lives. But so far, the pathological diagnosis of COVID-19 has been relatively deficient： it is still confined to the pathological findings of punctured organs, and the majority of medical workers have poor awareness of its pathological characteristics. The COVID-19, as same as SARS and MERS, is caused by coronaviruses and can cause viral pneumonia. They have certain similarities. This article comprehensively reviews the pathological features observed in the autopsies of the aforementioned three diseases, in order to provide reference to the analysis of pathological changes of COVID-19. Related Articles | Metrics | Comments（0） Select Gross examination report of a COVID-19 death autopsy LIU Qian, WANG Rong-shuai, QU Guo-qiang, et al. 法医学杂志    2020, 36 (1): 21-23.   DOI: 10.12116/j.issn.1004-5619.2020.01.005 Abstract （5087）      PDF（pc） （2523KB）（41434）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0） Select 法医学杂志    2020, 36 (1): 24-28.   DOI: 10.12116/j.issn.1004-5619.2020.01.006 Abstract （290）      PDF（pc） （963KB）（2580）       Knowledge map    Save Related Articles | Metrics | Comments（0） Select 法医学杂志    2020, 36 (1): 29-34.   DOI: 10.12116/j.issn.1004-5619.2020.01.007 Abstract （354）      PDF（pc） （937KB）（2921）       Knowledge map    Save Related Articles | Metrics | Comments（0） Select Trial of Chloroquines in the Treatment of COVID-19 and Its Research Progress in Forensic Toxicology DUAN Yi-jie*, LIU Qian*, ZHAO Shu-quan, et al. 法医学杂志    2020, 36 (2): 157-163.   DOI: 10.12116/j.issn.1004-5619.2020.02.002 Abstract （419）      PDF（pc） （943KB）（1335）       Knowledge map    Save Chloroquines are the long-established prescription drug, which are often used clinically to treat malaria and connective tissue diseases. Since December 2019, corona virus disease 2019 （COVID-19） outbreaks caused by 2019 novel coronavirus （2019-nCoV） has occurred in China and many countries around the world. Due to the lack of drugs against COVID-19, the disease spreads rapidly and the mortality rate is relatively high. Therefore, specific drugs against 2019-nCoV need to be quickly screened. The antimalarial drug chloroquine phosphate which has already been approved is confirmed to have an anti-2019-nCoV effect and has been included in diagnostic and therapeutic guidelines. However, awareness of the risk of chloroquine phosphate causing acute poisoning or even death should be strengthened. The current dosage recommended in clinical treatment is larger than that in previous treatment of malaria and the period of treatment is longer. Many provinces have required close clinical monitoring of adverse reactions. This paper reviews the pharmacological effects, poisoning and toxicological mechanisms, in vivo metabolism and distribution, and forensic issues of chloroquine drugs, in order to provide help to forensic practice and clinical work. Reference | Related Articles | Metrics | Comments（0） Select Retrospective Analysis of 61 Cases of Children Died of Viral Pneumonia CHEN Xue-bing, DU Si-hao, LU Jian-cong, et al 法医学杂志    2020, 36 (2): 164-168.   DOI: 10.12116/j.issn.1004-5619.2020.02.003 Abstract （442）      PDF（pc） （923KB）（1391）       Knowledge map    Save Objective To retrospectively analyze the forensic pathological postmortem examination and clinical data of children who died of viral pneumonia in identification of cause of death cases and to discuss the clinical characteristics and pathological features of viral pneumonia in children, in order to provide reference to pathological diagnosis of viral pneumonia in children caused by 2019 novel coronavirus （2019-nCoV） infection. Methods Postmortem examination data from 61 cases of children whose causes of death were identified as viral pneumonia in recent years were collected from the Center of Forensic Identification, Southern Medical University. The gender, age, clinical symptoms and pathological features were comparatively analyzed. Results Among the 61 cases of children who died of viral pneumonia, most were within 2 years old （83.61%）, and a large proportion died within 2 weeks after the onset of the disease （91.80%）. Gross changes in postmortem examination included respiratory mucosal hyperemia, pleural effusion, pulmonary swelling, variegated pulmonary pleura and serosa, as well as focal pulmonary hemorrhage and pulmonary edema. A large proportion of sick children had enlarged mesenteric lymph nodes （83.61%） and thymic dysplasia （21.31%）. Histopathological changes included edema of alveoli and interstitial substance, pneumorrhagia，shedding of alveolar epithelial cells, serous and （or） fibrous exudation in the alveoli, formation of viral inclusions, formation of transparent membranes, infiltration of inflammatory cells that mainly consisted of macrophages and lymphocytes in interstitial substance and alveoli. Viral infections often affected the heart and gastrointestinal tract. Conclusion The clinical symptoms of children with viral pneumonia are difficult to notice, and because the immune systems of children are not fully developed and they have poor immunity, they can easily become severely ill and even die. Analyzing the forensic autopsies and the histopathological characteristics could provide reference for pathological diagnosis of viral pneumonia. Related Articles | Metrics | Comments（0） Select 法医学杂志    2020, 36 (2): 169-173.   DOI: 10.12116/j.issn.1004-5619.2020.02.004 Abstract （156）      PDF（pc） （860KB）（732）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0） Select 法医学杂志    2020, 36 (2): 176-180.   DOI: 10.12116/j.issn.1004-5619.2020.02.006 Abstract （253）      PDF（pc） （856KB）（1051）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0） Select Application Prospects of Virtual Autopsy in Forensic Pathological Investigations on COVID-19 LI Rui*, YIN Kun*, ZHANG Kai, et al. 法医学杂志    2020, 36 (2): 149-156.   DOI: 10.12116/j.issn.1004-5619.2020.02.001 Abstract （587）      PDF（pc） （932KB）（1606）       Knowledge map    Save Autopsy of patients who died of infectious diseases is of significance for public health management. Few forensic autopsies have been performed since the outbreak of the corona virus disease 2019 （COVID-19） due to some limitations, thus forensic pathological examination failed to contribute to  the prevention and treatment of infectious diseases. Virtual autopsy has unique advantages in the forensic examination of patients who died of infectious diseases. Accumulated virtual autopsy image data are of great value to the study of the pathological mechanism and diagnosis of COVID-19. This article reviews the relationship between imaging changes and pathology of the COVID-19 as well as the application of virtual autopsy in autopsy of patients who died of infectious diseases, in order to provide reference for performing virtual autopsy in the outbreak of COVID-19. Reference | Related Articles | Metrics | Comments（0） Select   法医学杂志    2020, 36 (2): 174-175.   DOI: 10.12116/j.issn.1004-5619.2020.02.005 Abstract （158）      PDF（pc） （821KB）（719）       Knowledge map    Save   Reference | Related Articles | Metrics | Comments（0）