法医学杂志

法医学杂志 ›› 2020, Vol. 36 ›› Issue (3): 379-388.DOI: 10.12116/j.issn.1004-5619.2020.03.016

• 综述 • 上一篇    下一篇

遗传基因多态性与精神分裂症患者暴力行为关系的研究进展

徐烁1， 梁艺颖1， 洪彬雪1， 刘祥2， 刘元元1   

  1. 1. 四川大学华西公共卫生学院/四川大学华西第四医院 流行病与卫生统计学系，四川 成都 610041； 2. 四川大学华西公共卫生学院/四川大学华西第四医院 健康与社会行为学系，四川 成都 610041
  • 发布日期:2020-06-25 出版日期:2020-06-28
  • 通讯作者: 刘元元，女，副教授，主要从事分类预测与风险评估、统计分析方法在精神卫生领域的应用、临床试验统计分析等研究；E-mail：y_multi@126.com
  • 作者简介:徐烁（1994—），女，主要从事流行病与卫生统计学研究；E-mail：shuoxu94@hotmail.com
  • 基金资助:
    国家自然科学基金资助项目（81903414）；四川省科技厅资助项目（2019YJ0076）

Research Progress on the Relationship between Genetic Polymorphism and Violent Behavior of Patients with Schizophrenia

XU Shuo1, LIANG Yi-ying1, HONG Bin-xue1, LIU Xiang2, LIU Yuan-yuan1   

  1. 1. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China; 2. Department of Health-related Social and Behavioral Sciences, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China
  • Online:2020-06-25 Published:2020-06-28

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摘要： 精神分裂症是一种以思维障碍为主要表现，同时伴有感知、情感和行为方面障碍的常见疾病。患者可以在精神症状的支配下，出现自伤或冲动伤人行为，造成公共危害，增加家庭和社会负担。近年来陆续有研究表明精神分裂症患者的暴力行为与遗传因素相关联。本文综述了遗传基因多态性与精神分裂症患者暴力行为关系的研究进展，分析了两者间形成关联的可能机制，提出了目前研究存在的局限性以及未来的研究方向，为精神分裂症患者暴力行为的风险评估和预防控制提供科学依据。

关键词: 司法精神病学；法医遗传学；精神分裂症；多态现象, 遗传；暴力；综述

Abstract: Schizophrenia is a common disease characterized by thinking obstructions and accompanied by cognitive, emotional and behavioral disorders. Under the control of psychiatric symptoms, patients with schizophrenia may self-injure or impulsively wound others, resulting in public risk and increase in the burden of family and society. In recent years, many studies have shown that the violent behavior of patients with schizophrenia is related to genetic factors. This article reviews the research progress on the relationship between genetic polymorphism and violent behavior of patients with schizophrenia, analyzes the possible mechanism of the correlation between the two, puts forward the limitations of current research and the directions of future research, and provides scientific basis for risk assessment and prevention of violent behavior of patients with schizophrenia.

Key words: forensic psychiatry, forensic genetics, schizophrenia, polymorphism, genetics, violence, review