法医学杂志

法医学杂志 ›› 1988, Vol. 0 ›› Issue (1): 12-15.

• 论文 • 上一篇    下一篇

Gc亚型在鉴定亲子关系中的应用

朱永明;张工梁;赵桐茂;   

  1. 上海市输血研究所,上海市输血研究所,上海市输血研究所,
  • 发布日期:1988-02-25 出版日期:1988-02-28

The Use Gc Subtypes in Paternity Testing

ZHU YONGMING;ZHANG GONGLIANG;ZHAO TONGMAO   

  • Online:1988-02-25 Published:1988-02-28

摘要： <正> 1959年Hirschfeld用免疫电泳方法研究人血清α_2—球蛋白时,发现一些与Hp无关的沉淀带,根据其迁移率可以分为快速、中速和慢速三种。这类蛋白被称为型特异性成分Gc(Group-Specific Compon-ent),受控于常染色体上的两个共显性等位基因Gc~1和Gc~2。而后进一步研究发现Gc的主要生理功能是结合并传递维生素D,故又被称为维生素D结合蛋白。

Abstract: A total of 128 individuals from 40 disputed paternity cases were determined for Gc subtypes with isoelectric focusing followed by immunoblotting.The exclusion probabilities of Gc subtypes were 36.26％ for expected and 44.44％ for observed.No cases with Gc subtypes were found to be inconsistent with HLA,Gm,and other genetic markers.