法医学杂志

法医学杂志 ›› 1994, Vol. 0 ›› Issue (2): 0-0.

• 论文 •    

酒精对乌头碱毒物动力学的影响

徐威，胡炳蔚   

  1. 西安医科大学法医系毒理教研室
  • 发布日期:1994-04-25 出版日期:1994-04-28

INFUENCES OF ETAHNOL ON TOXICOKINETICS OF ACONIFTNE IN RABBITS

XU WEI;HU BINGWEI(DEPARTMENT OF TOXICOLOGY, FACULTY OF FORENSIC MEDICINE,XIAN MEDICAL UNIVERSITY;XIAN, 710061 )   

  • Online:1994-04-25 Published:1994-04-28

被引次数

19

摘要： 用反相高效液相色谱法测定生物样品中的乌头碱．给新西兰兔灌服１．５ｇ／ｋｇ短柄乌头后，乌头碱在免休内的毒物动力学过程为二室开放模型，其Ｋａ、Ａ、Ｂ值分别为１．１６２９±０．４０５３，０．６０４６±０．２５７４，１．１６０７±０．３７８１ｕｇ／ｍｌ．研究了灌服５．７５ｇ酒精对该动力学过程的影响，表明酒精不改变其模型类型，但可明显加速乌头碱的吸收和分布（Ｐ＜０．０１），对消除过程无明显影响，其Ｋａ、Ａ、Ｂ值分别为２．４０２６±０．５３７６，１．２０５１±０．５３２８，１．２０３７±０．４０９５μｇ／ｍｌ。说明酒精可增加短柄乌头的毒性。

关键词: 高效液相色谱法, 酒精, 乌头碱, 毒物动力学

Abstract: A reverse - phase High - performance liquid chromatography for the detection of aconitine concentration in biological samples of rabbits was used. This method showed good linearity,precision and accuracy over range of 0. 05 5ug/ml. After ig Aconitum brachypodum Diels 1. 5g/kg, it was showed that aconitine was a two-conmpartnlent open model drug in rabbits.Ka,A and B were 1. 1629± 0. 4053, 0. 6045 ±0. 2574, 1. 1607± 0. 3781 ug/ml separately. The influence of ethanol on toxicokinetics of aconitine in blood samples of rabbits indicated that absorption rate constant and distribution rate constant in ethanol group were greater than those in control group (p< 0. 01 ). However, there were no significant differences be tween elimination rate constant of the two groups. Ka, A and B are 2. 4026 ± 0. 4053,1. 2051 ± 0. 5328, 1. 2037 ± 0.4095 ug/ml separately. Our data suggested that ethanol causes the lucrease of toxicity of Aconitum brachypodum Diels.

Key words: aconitine, ethanol, HPLC, interaction, toxicokinetics