法医学杂志

法医学杂志 ›› 1996, Vol. 0 ›› Issue (4): 0-0.

• 论文 •    

怀疑原发性脑干损伤早期死亡脑干纤维联结蛋白的免疫组化研究

周伟，祝家镇，徐小虎   

  1. 中山医科大学法医病理教研室
  • 发布日期:1996-08-25 出版日期:1996-08-28

Brain-Stem Fibronectin Studies Immunohistochemically in Early Dying Cases of Suspected Primary Brain-Stem Injury

ZHOU WEI ET. AL. (DEPARTMENT OF FORENSIC PATHOLOGY,YAT SUN UNIVERSITY OF MEDICAL SCIENCES,GUANG-ZHOU 510089)   

  • Online:1996-08-25 Published:1996-08-28

被引次数

7

摘要： 在本研究的１３个案例中，怀疑原发性脑干伤死亡的５例，明确死因的８例，其中严重闭合性颅脑损伤２例；缢死１例，失血性休克１例，电击２例，海洛因中毒２例。用ＬＳＡＢ法对１３例脑干的中脑、脑桥、延髓各部ＦＮ进行检测。结果显示５例怀疑为原发性脑干伤、２例严重颅脑损伤、２例海洛因中毒死者的脑千部位的神经元内均可见ＦＮ的异常沉积，其它各例未见ＦＮ的异常沉积。结果表明；ＬＳＡＢ－ＦＮ法是诊断原发性脑干伤早期死亡灵敏但非特异的形态学指标。

关键词: 原发性脑干损伤, 纤维联结蛋白（FN）, 免疫组织化学

Abstract: In the thirteen cases studied below. five are suspected primary brain-stem injury,the other eight are clear in the cause of death,including severe closed craniocerebral injury(2 cases),hanging(1 case),hemorrhagic shock(1 case),death from electricity(2 cases) and heroin poisoning(2 cases).FN in brain-stem (midbrain pons and medullary bulb) is detected in some brain-stem neurons in all cases of the suspected primary brain-stem injury, severe craniocerebral injury and beroin poisoning.Thus LSAB-FN method is not specific but very sensitive morphologic parameter of primary brain-stem injury

Key words: primary brain-stem injury, Fibronectin, immnohistochemistry