法医学杂志

法医学杂志 ›› 2002, Vol. 0 ›› Issue (2): 112-114.

• 论文 • 上一篇    下一篇

NF-κB对神经系统的发育和调节作用

陈溪萍,陶陆阳,丁梅,官大威   

  1. 中国医科大学法医学院,中国医科大学法医学院,中国医科大学法医学院,中国医科大学法医学院 辽宁沈阳110001 ,辽宁沈阳110001 ,辽宁沈阳110001 ,辽宁沈阳110001
  • 发布日期:2002-04-25 出版日期:2002-04-28

Influence of NF-κB on the development and regulation of neural system

CHEN XI-PING,TAO LU-YANG,DING MEI,ET AL.(CHINA MEDICAL UNIVERSITY SCHOOL OF FORENSIC MEDICINE,SHENYANG110002)   

  • Online:2002-04-25 Published:2002-04-28

摘要： 细胞核因子κB(Nuclearfactor-κB,NF-κB)对感染、免疫反应以及控制细胞分化和凋亡起到广泛的作用。这些作用在神经系统中较为明显。NF-κB通常以多种亚单位形式存在于各种神经细胞中,并通过多种激活途径被激活后从胞浆易位至细胞核内发挥转录激活作用。NF-κB在对神经系统发育和抗凋亡中以及调节胶质细胞活性过程中起到至关重要的作用,对NF-κB的有关研究对法医学将具有重要的指导意义。

关键词: NF-κB, 凋亡, 法医学

Abstract: Nuclear factor-κB(NF-κB)plays an important role in controlling infection,immunity responses,cellar differentiation and apoptosis.It is of characteristics especially in neural system.NF-κB exist widely in neural cells and transfer from plasma into nucleolus through diversified activation passages.in addition,NF-κB is also a key factor in the development of the neural system,anti-apoptosis and modulating the activity of glia cells.It is of great significance in the forensic science.

Key words: NF-κB, apoptosis, forensic medicine