法医学杂志

法医学杂志 ›› 2005, Vol. 0 ›› Issue (2): 159-161+.

• 论文 • 上一篇    下一篇

DNA芯片分析单核苷酸多态性及其法医学应用

白鹏,田力,周雪平,高玉振,吴谨   

  1. 四川大学华西基础医学与法医学院,四川大学华西基础医学与法医学院,四川大学华西基础医学与法医学院,苏州大学医学院法医教研室,四川大学华西基础医学与法医学院 四川成都610041 ,四川成都610041 ,四川成都610041 ,江苏苏州215007 ,四川成都610041
  • 发布日期:2005-04-25 出版日期:2005-04-28

The Joint Applications of DNA Chips and Single Nucleotide Polymorphisms in Forensic Science

BAI PENG, TIAN LI, ZHOU XUE-PING, ET AL. (COLLEGE OF PRECLINICAL AND FORENSIC MEDICINE,SICHUAN UNIVERSITY,CHENGDU 610041, CHINA)   

  • Online:2005-04-25 Published:2005-04-28

被引次数

7

摘要： DNA芯片技术作为一门新兴的高科技生物技术,显示了它旺盛的生命力和迅猛的发展势头。单核苷酸多态性(SingleNucleotidePolymorphisms,SNPs)是最常见的人类基因组变异类型。它作为一种有效的人类遗传标记,在疾病相关性研究、药物基因组学、法医学、人类进化和迁移等研究中发挥了重要作用。它同DNA芯片技术结合运用也将在法医检验,尤其是亲子鉴定和个人识别中发挥重要作用。本文主要讨论了DNA芯片和SNPs的特点,以及二者联合运用于法医学的价值。

关键词: DNA芯片, 单核苷酸多态性, 法医学, 应用

Abstract: DNA chip technology, being a new high-technology, shows its vigorous life and rapid growth. Single Nucleotide Polymorphisms (SNPs) is the most common diversity in the human genome. It provides suitable genetic markers which play a key role in disease linkage study,pharmacogenomics,forensic medicine,population evolution and immigration study. Their advantage such as being analyzed with DNA chips technology, is predicted to play an important role in the field of forensic medicine, especially in paternity test and individual identification. This report mainly reviews the characteristics of DNA chip and SNPs,and their joint applications in the practice of forensic medicine.

Key words: DNA chip, single nucleotide polymorphisms, forensic medicine, applications