法医学杂志

法医学杂志 ›› 2006, Vol. 0 ›› Issue (2): 159-162.

• 论文 • 上一篇    下一篇

MiniSTR技术的研究进展

王会品;刘超;孙宏钰;   

  1. 中山大学基础医学院法医学系,广州市刑事科学技术研究所,中山大学基础医学院法医学系 广东广州510080广州市刑事科学技术研究所,广东广州510030,广东广州510030,广东广州510080
  • 发布日期:2006-04-25 出版日期:2006-04-28

Recent Advancement in MiniSTR Research

WANG HUI-PIN1, LIU CHAO2, SUN HONG-YU1 (1. DEPARTMENT OF FORENSIC BIOLOGY, SUN YAT-SEN UNIVERSITY, GUANGZHOU 510080, CHINA; 2. GUANGZHOU CRIMINAL SCIENCE ﹠ TECHNOLOGY INSTITUTE, GUANGDONG 510030, CHINA)   

  • Online:2006-04-25 Published:2006-04-28

被引次数

62

摘要： 短串联重复序列(STR)是法医DNA鉴定中最常用和最重要的遗传标记,但是对于降解和微量的DNA样品,经常得不到完整的DNA分型甚至分型失败。MiniSTR技术通过设计更靠近重复序列的引物,得到更短一些的STR基因座,提高了降解和微量检材的DNA分型成功率。本文综述了miniSTR技术的研究进展,以服务于法医学实践。

关键词: MiniSTR, 降解DNA, 法医DNA分型

Abstract: As the most popular and important inherited marker used in forensic identification, short tandem repeat (STR) always have partial DNA profiling or even no results when handling degraded or minute DNA sample. Through redesigning primers close to STR core repeats, MiniSTR can access shorter STR loci and increase success rate of DNA profiling in degraded or minute DNA sample. The review provides an update on the advancement of miniSTR research to give information in the practice of forensic science.

Key words: miniSTR, degraded DNA, forensic DNA profiling