法医学杂志

法医学杂志 ›› 2010, Vol. 26 ›› Issue (5): 328-331.DOI: 10.3969/j.issn.1004-5619.2010.05.003

• 论著 • 上一篇    下一篇

CAR在病毒性心肌炎和扩张型心肌病心肌中的表达

许弘飞1，2，陈建雷3，达徐平1，吴克荣1，刘国庆1，赵子琴2，韩新华1   

  1. （1. 南通大学 医学院法医学教研室，江苏 南通 226001； 2. 复旦大学 上海医学院法医学系，上海 200222； 3. 启东市公安局 刑警大队，江苏 启东 226200）
  • 发布日期:2010-10-25 出版日期:2010-10-28
  • 通讯作者: 通信作者：韩新华，男，主任医师，主要从事法医病理学研究；E－mail：hxh@ntu.edu.cn
  • 作者简介:许弘飞（1980—），男，安徽芜湖人，博士研究生，主要从事心源性猝死的法医病理学研究；E－mail：whhongfei@sina.com

Expression of CAR in Myocardial of Viral Myocarditis and Dilated Cardiomyopathy

XU HONG-FEI1,2, CHEN JIAN-LEI3, DA XU-PING1, WU KE-RONG1, LIU GUO-QING1, ZHAO ZI-QIN2, HAN XIN-HUA1   

  1. （1. Department of Forensic Medicine, Medical College of Nantong University, Nantong 226001, China;  2.  Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai 200222, China; 3. Criminal Police Brigade of Qidong Public Security Bureau, Qidong 226200, China）
  • Online:2010-10-25 Published:2010-10-28

被引次数

21

摘要： 目的 探讨病毒性心肌炎（viral myocarditis，VMC）和扩张型心肌病（dilated cardiomyopathy，DCM）的发病机制及相互关系，从而提高心源性猝死法医学鉴定的可靠性和准确性。 方法 对VMC组22例、DCM组20例和对照组16例的心肌组织中柯萨奇-腺病毒受体（coxsackie-adenovirus receptor，CAR）的表达进行改良的免疫组织化学研究。 结果 VMC组和DCM组心肌组织细胞膜呈现深棕黄色阳性颗粒，有较高水平的CAR表达，与对照组比较，差异有统计学意义（P<0.05），对照组染色阴性。 结论 VMC和DCM组心肌中CAR的高表达，提示VMC和DCM的发病机制可能与病毒感染有关，病毒感染并破坏心肌细胞导致心肌细胞坏死，心功能受损，使VMC进展为DCM。

关键词: 法医病理学, 猝死, 心脏, 心肌病, 扩张型, 病毒性心肌炎, 柯萨奇-腺病毒受体

Abstract: Objective In order to improve accuracy and reliability of forensic diagnosis of sudden cardiac death, pathogenesis and relationship between the viral myocarditis（VMC） and dilated cardiomyopathy（DCM） were investigated. Methods Improved immunohistochemical technique was used to detect the expression of the CAR in myocardium samples， including 22 deceased with VMC, 20 deceased with DCM and 16 control deceased. Results The brown staining on the cell membrane of myocardium showed positive result. There was a prominent CAR expression in VMC group and DCM group , which were statistically significant difference compared with control group（P<0.05）. Conclusion The CAR expression showed significantly higher in VMC and DCM groups. The viral infection can result in myocardial necrosis and impaired cardiac functions. These abnormalities can trigger a cascade of events that contributed to the progress of VMC to DCM.

Key words: forensic pathology, death, sudden, cardiac, cardiomyopathy, dilated, viral myocarditis, coxsackie-adenovirus receptor

中图分类号: