法医学杂志

法医学杂志 ›› 2014, Vol. 30 ›› Issue (4): 267-269.DOI: 10.3969/j.issn.1004-5619.2014.04.008

• 案例分析 • 上一篇    下一篇

142例过敏性休克死亡法医病理学分析

胡东阳1，黄  翠2，刘双高3，黄  雷4，郑金祥4，黄二文4，吴秋萍4，成建定4，唐双柏4   

  1. （1. 南阳市中级人民法院，河南 南阳 473000； 2. 黄山市中医院针灸科，安徽 黄山 245000； 3. 广州军区广州总医院附属第157医院临床部，广东 广州 510510； 4. 中山大学中山医学院法医病理学教研室，广东 广州 510080）
  • 发布日期:2014-08-25 出版日期:2014-08-28
  • 通讯作者: 唐双柏，男，博士，副主任法医师，主要从事法医病理学及法医临床学研究；E-mail：tangshb@mail.sysu.edu.cn
  • 作者简介:胡东阳（1968—），男，河南南阳人，主检法医师，主要从事法医病理学及法医临床学研究；E-mail：dongyangzi@ 126.com
  • 基金资助:

    广东省自然科学基金资助项目（S2012010009045）

Death Caused by Anaphylactic Shock： A Forensic Pathological Analysis of 142 Cases

HU DONG-YANG1, HUANG CUI2, LIU SHUANG-GAO3, HUANG LEI4, ZHENG JIN-XIANG4, HUANG ER-WEN4, WU QIU-PING4, CHENG JIAN-DING4, TANG SHUANG-BO4   

  1. （1. Nanyang Intermediate People’s Court, Nanyang 473000, China; 2. Department of Acupuncture, Traditional Chinese Medical Hospital of Huangshan, Huangshan 245000, China; 3. Clinical Department, 157th Hospital Affiliated to Guangzhou General Hospital of Guangzhou Military Command of PLA, Guangzhou 510510, China; 4. Teaching and Research Office of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China）
  • Online:2014-08-25 Published:2014-08-28

被引次数

12

摘要： 目的 探讨过敏性休克死亡案例的特点。 方法 对142例过敏性休克死亡案例进行回顾性分析，并对过敏性休克死亡案例与62例非过敏性休克死亡案例的血清IgE水平进行统计分析。 结果 过敏性休克死亡大多发生于医疗机构，占77.46%。采用单纯静脉给药方式致过敏性休克死亡案例占53.53%。β-内酰胺类抗生素、糖皮质激素类药物、中药制剂在过敏性休克死亡案例生前治疗药物中占有重要比例。过敏性休克死亡案例多无特异性组织病理学改变，与非过敏性休克死亡组的血清IgE水平的差异具有统计学意义（P＜0.05）。 结论 过敏性休克死亡案例死因鉴定应根据案情、解剖检验结果及血清IgE水平等检测指标进行综合分析判定。

关键词: 法医病理学, 过敏反应, 免疫球蛋白E

Abstract: Objective To explore the forensic pathological features of death caused by anaphylactic shock. Methods One hundred and forty-two death cases of anaphylactic shock were retrospectively analyzed. The IgE level in the serum of anaphylactic shock cases were statistically compared with that of 62 non-anaphylactic shock cases. Results Most cases （77.46%） of anaphylactic shock death occurred in the medical institutes, with intravenous drug administration accounting for 53.53% of anaphylactic shock death. β-lactam antibiotics, glucocorticoid and herbal medications were responsible for a significant proportion of such cases. Although characteristic histopathological changes were absent in vast majority of these anaphylactic shock cases, the differences of IgE levels in the serum between anaphylactic shock group and non-anaphylactic shock group were statistically significant （P<0.05）. Conclusion Combined information including clinical data, autopsy results, IgE level, and other specific test results should be evaluated together in the forensic pathological diagnosis of anaphylactic shock.

Key words: forensic pathology, anaphylactic reaction, immunoglobulin E

中图分类号: