法医学杂志 ›› 2017, Vol. 33 ›› Issue (2): 171-174.DOI: 10.3969/j.issn.1004-5619.2017.02.014

• 综述 • 上一篇    下一篇

心肌梗死和心脏传导系统病变在心源性猝死中的作用

宋如莹1,2,丁润涛2,崔  文2   

  1. (1. 青岛大学医学部,山东 青岛 266000; 2. 济宁医学院法医学与医学检验学院,山东 济宁 272067)
  • 发布日期:2017-04-25 出版日期:2017-04-28
  • 通讯作者: 崔文,男,教授,主要从事法医病理学研究;E-mail:cuiwenmd@163.com
  • 作者简介:宋如莹(1989—),女,硕士研究生,主要从事心肌梗死与心脏传导系统异常的相关性研究;E-mail:ruyingsong@ 163.com

Impact of Myocardial Infarction and Abnormalities of Cardiac Conduction System on Sudden Cardiac Death

SONG RU-YING1,2, DING RUN-TAO2, CUI WEN2   

  1. (1. Medical College of Qingdao University, Qingdao 266000, China; 2. Forensic Medicine and Medical Laboratory Science of Jining Medical University, Jining 272067, China)
  • Online:2017-04-25 Published:2017-04-28

摘要: 心源性猝死(sudden cardiac death,SCD)是由心脏原因引起的突然死亡,最常见于冠心病,且很多合并心肌梗死。但某些SCD(包括早期心肌梗死)由于发生突然,在极短的时间内即可引起死亡,肉眼和镜下缺乏典型的形态学改变,是目前研究的重点及难点。心肌梗死与心脏传导系统(cardiac conduction system,CCS)异常引起SCD的原因都与冠状动脉粥样硬化密切相关,本文从形态学和分子生物学两个方面入手,对心肌梗死与CCS病变引起心脏功能障碍的相关研究进行综述,以进一步揭示两者之间的相关性,对今后心肌梗死引起猝死机制方面的研究提供线索,为SCD的法医学诊断提供帮助。

关键词: 法医病理学, 猝死, 心脏, 综述, 冠心病, 心肌梗死, 心脏传导系统

Abstract:  Sudden cardiac death (SCD), most commonly seen in coronary heart disease, is a kind of sudden death caused by series of cardiac parameters, which usually combines with myocardial infarction. However, some SCDs (including early myocardial infarction) happen suddenly and cause death in a very short time. In these circumstances, typical morphological changes are lack in macroscopic or microscopic fields, which make such SCDs become the emphasis and difficulty in the present research. SCD caused by myocardial infarction and abnormalities of cardiac conduction system (CCS) is related to atherosclerosis of coronary artery closely. This paper reviews cardiac dysfunction caused by myocardial infarction and diseases of CCS from morphology and molecular biology, and explores potential relationship between them. This paper aims to provide clues to the mechanism of myocardial infarction related sudden death and possible assistance for forensic diagnosis of SCD.

Key words:  forensic pathology, death, sudden, cardiac, review, coronary disease, myocardial infarction, cardiac conduction system

中图分类号: