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法医学杂志 2018, Vol. 34 Issue (3) :233-235;252    DOI: 10.12116/j.issn.1004-5619.2018.03.003
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雌性大鼠小肠内容物迁移距离与餐后存活时间的关系
陈  林1,方俊杰1,孟  刚2,肖圣兵1,秦  明1,万  阳2
1. 安徽省公安厅物证鉴定中心,安徽 合肥 230061; 2. 安徽医科大学第四附属医院临床病理中心,安徽 合肥 230022
Correlation between Movement Distance of Small Intestinal Contents and Survival Time in Female Rats after Feeding#br#
CHEN Lin1, FANG Jun-jie1, MENG Gang2, XIAO Sheng-bing1, QIN Ming1, WAN Yang2
1. Institute of Forensic Science, Department of Anhui Public Security, Hefei 230061, China; 2. Clinical Pathology Center, the Fourth Affiliated Hospital of Anhui Medical University, Hefei 230022, China

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摘要 目的 研究雌性SD大鼠动物模型进食后小肠内容物迁移距离与餐后存活时间的关系,并评估其在死亡时间推断中的应用价值。 方法 将成年雌性SD大鼠随机分为餐后1、2、3、4、5 h组及对照组。各实验组同时饲食1 h后撤去食物,对照组不予饲食,分别在上述时间点处死大鼠,对胃及小肠内容物进行观察、描述、比对及拍照固定,测量小肠内容物迁移距离,并对实验组数据进行单因素方差分析。 结果 对照组胃腔及十二指肠空虚,其内可见少量稀薄黄色小肠液。餐后1 h组,大鼠胃腔充盈饱满,其内充满未消化的食物,其余各实验组胃及小肠内容物性状、色泽及含量均存在渐进性变化,小肠空白区逐渐缩短,小肠内容物迁移距离逐渐延长,各实验组间比较差异具有统计学意义(P<0.05)。 结论 雌性SD大鼠通过禁食不禁水24 h后自由进食1 h可成功建立理想的、可用于固定及测量小肠内容物迁移距离的动物模型,该模型可为法医学鉴定实践中利用小肠内容物推断死亡时间提供实验依据。
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陈林
方俊杰
孟刚
关键词法医病理学;模型   动物;胃肠内容物;迁移距离;死亡时间;大鼠     
Abstract: Objective To study the correlation between the movement distance of small intestinal contents and survival time in female SD rat models after one-time satiation, and to evaluate its application value for postmortem interval estimation. Methods Adult female SD rats were randomly divided into postprandial groups (1, 2, 3, 4 and 5 h after feeding) and control group. The postprandial groups were fed for 1 h, meanwhile control group was kept fasting. All rats were sacrificed at the given time. The contents in stomach and small intestine were observed, described, compared and photographed, and the movement distance of small intestinal contents was measured. The data of postprandial groups were analysed by one-way analysis of variance. Results The stomach and duodenum of control group were empty with a little thin and yellow small intestinal liquid. The gastral cavities of 1 h postprandial group were full of undigested food. The evolutionary changes of character, colour and content were observed in the gastric and small intestinal contents of other postprandial groups. The movement distance of intestinal contents increased while the empty part decreased gradually. The differences among the postprandial groups were statistically significant (P<0.05). Conclusion After a 24 h fasting with free drinking and the following 1 h feeding, an ideal animal model can be established successfully on female SD rats, which can provide an experimental basis for postmortem interval estimation based on the changes of small intestinal contents in forensic practice.
Keywordsforensic pathology   models, animal   gastrointestinal contents   migration distance   postmortem interval   rats     
Fund:安徽省科技强警计划资助项目(1101b0403036)
About author: 陈林(1965—),男,主任法医师,主要从事法医病理学与法医临床学研究;E-mail:2523087@qq.com
引用本文:   
陈林,方俊杰,孟刚,等.雌性大鼠小肠内容物迁移距离与餐后存活时间的关系[J]  法医学杂志, 2018,34(3): 233-235;252
CHEN Lin, FANG Jun-jie, MENG Gang,et al .Correlation between Movement Distance of Small Intestinal Contents and Survival Time in Female Rats after Feeding#br#[J]  , 2018,34(3): 233-235;252
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