法医学杂志 ›› 2019, Vol. 35 ›› Issue (1): 78-83.DOI: 10.12116/j.issn.1004-5619.2019.01.015

• 综述 • 上一篇    下一篇

蛋白质组学及其在法医病理学中的应用

韩刘君,徐红梅,陈龙   

  1. 复旦大学基础医学院法医学系,上海 200032
  • 发布日期:2019-02-25 出版日期:2019-02-28
  • 通讯作者: 陈龙,男,博士,教授,博士研究生导师,主任法医师,主要从事法医病理学及法医毒理学的教学、研究及鉴定;E-mail: chenlong@shmu.edu.cn
  • 作者简介:韩刘君(1991—),女,硕士研究生,主要从事法医病理学研究;E-mail:16211010070@fudan.edu.cn
  • 基金资助:
    国家自然科学基金资助项目(81671863,81373242,81172896)

Proteomics and Its Application in Forensic Pathology

HAN Liu-jun, XU Hong-mei, CHEN Long   

  1. Department of Forensic Medicine, School of Basic Medicine Sciences, Fudan University, Shanghai 200032, China
  • Online:2019-02-25 Published:2019-02-28

摘要: 蛋白质组学已成为现代生命科学领域中的热点之一,其应用前景已在临床医学研究中得到印证,如发现新的疾病生物标志物、鉴定疾病相关蛋白质、开发新的药物靶点等,但在法医学领域尤其是法医病理学领域尚处于探索阶段。本文从研究技术以及国内外学者将蛋白质组学技术应用于法医病理学的研究进展进行综述,以期为法医病理学的研究和应用提供新思路。

关键词: 法医病理学, 蛋白质组学, 死亡时间, 死亡原因, 综述

Abstract: Proteomics has become one of the hot topics in modern life sciences. Its application prospects have been confirmed in clinical medical research, such as the discovery of new disease biomarkers, identification of disease-related proteins, and development of new drug targets. However, in the field of forensic science, especially in forensic pathology, it is still in the stage of exploration. This paper reviews the research techniques and the use of proteomics in forensic pathology in domestic and foreign scholars, in order to provide new ideas for the research and application of forensic pathology.

Key words: forensic pathology, proteomics, postmortem interval, cause of death, review