法医学杂志

法医学杂志 ›› 2020, Vol. 36 ›› Issue (1): 99-103.DOI: 10.12116/j.issn.1004-5619.2020.01.019

• 综述 • 上一篇    下一篇

胰岛素过量致低血糖脑损伤神经病理学研究进展

童昉1， 杨怡2， 梁悦1， 罗桑旦增1， 刘育洛1， 赵枢泉1， 何光龙3， 周亦武1   

  1. 1. 华中科技大学同济医学院法医学系，湖北 武汉 430030； 2. 武汉市公安局汉阳区分局，湖北 武汉 430050； 3. 公安部物证鉴定中心，北京 100038
  • 发布日期:2020-02-25 出版日期:2020-02-28
  • 通讯作者: 何光龙，男，硕士，副主任法医师，主要从事法医病理学损伤类案件检验、科研及培训；E-mail：guanglong_he@163.com 周亦武，男，教授，博士研究生导师，主要从事法医病理学教学、研究及检案；E-mail：yiwuhedi@sina.com
  • 作者简介:童昉（1989—），男，博士，主要从事法医病理学研究；E-mail：drtongfang@163.com
  • 基金资助:
    国家重点研发计划资助项目（2018YFC0807203）

Advances in Neuropathologic Research of Hypoglycemic Brain Damage Caused by Insulin Overdose

TONG Fang1, YANG Yi2, LIANG Yue1, LOPSONG Tin-zen1, LIU Yu-luo1, ZHAO Shu-quan1, HE Guang-long3, ZHOU Yi-wu1   

  1. 1. Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; 2. Hanyang Branch of Wuhan Public Security Bureau, Wuhan 430050, China; 3. Institute of Forensic Science, Ministry of Public Security, Beijing 100038, China
  • Online:2020-02-25 Published:2020-02-28

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摘要： 胰岛素意外中毒、自杀，甚至他杀致死案件日趋增多，而胰岛素过量致死的法医学诊断极为困难。葡萄糖是大脑最主要的能量来源，因此低血糖脑损伤被认为是胰岛素过量致死的主要原因。近年来，胰岛素过量致低血糖脑损伤的研究逐渐在法医学领域受到重视，本文从法医神经病理学的角度，综述胰岛素过量致低血糖脑损伤的神经病理学改变、病理生理过程及潜在神经分子标志物，为法医学相关领域的科研及实践提供借鉴。

关键词: 法医病理学, 胰岛素, 脑损伤, 低血糖症, 综述

Abstract: The number of death from insulin overdose, including accidental poisoning, suicide and homicide, is increasing these years. The forensic diagnosis of death from insulin overdose is a tough task. Glucose is the main energy source of the brain. Therefore, hypoglycemic brain damage is considered to be the main reason of death from insulin overdose. Recently, research of hypoglycemic brain damage caused by insulin overdose is gradually being paid attention in the field of forensic medicine. This paper summarizes the neuropathologic changes, pathophysiologic process and potential neural molecular markers of hypoglycemic brain damage caused by insulin overdose in terms of forensic neuropathology, providing reference for the research and practice in forensic medicine related fields.

Key words: forensic pathology, insulin, brain damage, hypoglycemia, review