法医学杂志

法医学杂志 ›› 2020, Vol. 36 ›› Issue (2): 243-248.DOI: 10.12116/j.issn.1004-5619.2020.02.018

• 综述 • 上一篇    下一篇

线粒体缺氧性损伤及其法医学意义

胡毅恺1， 张恒1， 肖碧2， 陈龙1   

  1. 1. 复旦大学基础医学院法医学系，上海 200032； 2. 上海市公安局物证鉴定中心 上海市现场物证重点实验室，上海 200083
  • 发布日期:2020-04-25 出版日期:2020-04-28
  • 通讯作者: 陈龙，男，教授，主要从事法医临床学、法医病理学、法医物证学研究和鉴定以及解剖学教学和科研；E-mail：chenlong@shmu.edu.cn
  • 作者简介:胡毅恺（1994—），男，硕士研究生，主要从事法医临床学、法医病理学研究和鉴定；E-ma

Mitochondrial Damage due to Hypoxia and Its Forensic Significance

HU Yi-kai1, ZHANG Heng1, XIAO Bi2, CHEN Long1   

  1. 1. Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; 2. Shanghai Key Laboratory of Crime Scene Evidence, Institute of Forensic Science, Shanghai Public Security Bureau, Shanghai 200083, China
  • Online:2020-04-25 Published:2020-04-28

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摘要： 线粒体是真核细胞中特殊的细胞器，主要功能是进行氧化磷酸化合成细胞活动所需的能量，机体所摄入的氧气绝大部分都在线粒体中被消耗。机械性窒息的精准诊断是法医病理学实践中的难点之一，法医病理学工作者一直致力于寻找一种可靠、敏感的标志物用于机械性窒息的确诊。线粒体对于缺氧环境极为敏感，其损伤标志物或可作为诊断机械性窒息的依据。本文旨在综述缺氧环境下线粒体损伤的研究进展，并探索将线粒体损伤标志物用于法医病理学实践的可能性。

关键词: 法医病理学, 线粒体, 创伤和损伤, 缺氧, 机械性窒息, 综述

Abstract: Mitochondria are the special organelle in eukaryotic cells. Their main functions are to synthesize energy required for cell activity by oxidative phosphorylation. Most of the oxygen absorbed by the body is consumed in the mitochondria. The precise diagnosis of mechanical asphyxia is one of the difficulties in forensic pathology practice. Forensic pathologists have been trying to find a reliable and sensitive marker for the diagnosis of mechanical asphyxia. Mitochondria are very sensitive to hypoxic environments, and the markers of mitochondrion damage can be used as a basis for the diagnosis of mechanical asphyxia. The purpose of this paper is to review the research progress on mitochondrial damage in hypoxic environments and to explore the possibility of using markers of mitochondrion damage in forensic pathological practice.

Key words: forensic pathology, mitochondria, wounds and injuries, hypoxia, mechanical asphyxia, review