Research Progress of Chirp ABR and Its Application in Forensic Auditory Identification

doi:10.12116/j.issn.1004-5619.2024.240201

Abstract

Abstract:

The objective assessment of hearing loss is one of the critical components in forensic clinical research. Auditory brainstem response （ABR） is an important method for objectively assessing hearing levels. It is divided into various types based on different stimulus signals, each with its own characteristics and applications. Among them, narrow-band Chirp ABR, due to its frequency specificity, fulfills the basic requirements for objective assessment of forensic audiology, promising to be an important method of objective hearing assessment in forensic medicine. This article reviews the development history, characteristics, and clinical applications of Chirp ABR, and envisions its application prospects in forensic auditory identification.

Key words: forensic medicine, hearing ability, auditory evoked potential, auditory brainstem response, review

CLC Number:

Yan GAO, Fang CHEN, Wen-tao XIA, Xiao-ping YANG, Ze-yu WANG, Ze-ren YANG, Xia LIU, Yan-liang SHENG. Research Progress of Chirp ABR and Its Application in Forensic Auditory Identification[J]. Journal of Forensic Medicine, DOI: 10.12116/j.issn.1004-5619.2024.240201.

References 42

1	范飞，武娟，邓振华. 听力学客观检测技术在法医临床学中的应用进展[J].法医学杂志，2023，39（4）：360-366，372. doi：10.12116/j.issn.1004-5619.2023.230406 .
	FAN F， WU J， DENG Z H. Application progress of objective audiological detection techniques in forensic clinical medicine[J]. Fayixue Zazhi，2023，39（4）：360-366，372.
2	刘博. 诊断听力学[M].北京：人民卫生出版社，2022：123，148.
	LIU B. Diagnostic audiology[M]. Beijing： People’s Medical Publishing House，2022：123，148.
3	陈芳，杨小萍，范利华. 听觉诱发电位的研究进展[J].法医学杂志，2011，27（3）：211-215. doi：10.3969/j.issn.1004-5619.2011.03.015 .
	CHEN F， YANG X P， FAN L H. The progress in the study on auditory evoked potentials[J]. Fayixue Zazhi，2011，27（3）：211-215.
4	SHORE S E， NUTTALL A L. High-synchrony cochlear compound action potentials evoked by rising frequency-swept tone bursts[J]. J Acoust Soc Am，1985，78（4）：1286-1295. doi：10.1121/1.392898 .
5	ELBERLING C， DON M， CEBULLA M， et al. Auditory steady-state responses to chirp stimuli based on cochlear traveling wave delay[J]. J Acoust Soc Am，2007，122（5）：2772-2785. doi：10.1121/1.2783985 .
6	ELBERLING C， DON M. Auditory brainstem responses to a chirp stimulus designed from derived-band latencies in normal-hearing subjects[J]. J Acoust Soc Am，2008，124（5）：3022-3037. doi：10.1121/1.2990709 .
7	ELBERLING C， DON M. A direct approach for the design of chirp stimuli used for the recording of auditory brainstem responses[J]. J Acoust Soc Am，2010，128（5）：2955-2964. doi：10.1121/1.3489111 .
8	RODRIGUES G R I， RAMOS N， LEWIS D R. Comparing auditory brainstem responses （ABRs） to toneburst and narrow band CE-chirp in young infants[J]. Int J Pediatr Otorhinolaryngol，2013，77（9）：1555-1560. doi：10.1016/j.ijporl.2013.07.003 .
9	王小亚，梁小冰，罗仁忠. 频率特异性ABR临床应用的研究进展[J].听力学及言语疾病杂志，2020，28（6）：706-710. doi：10.3969/j.issn.1006-7299.2020.06.022 .
	WANG X Y， LIANG X B， LUO R Z. Research progress in clinical application of frequency-specific ABR[J]. Tinglixue Ji Yanyu Jibing Zazhi，2020，28（6）：706-710.
10	KEESLING D A， PARKER J P， SANCHEZ J T. A comparison of commercially available auditory brainstem response stimuli at a neurodiagnostic intensity level[J]. Audiol Res，2017，7（1）：161. doi：10 .
	4081/audiores.2017.161.
11	ROSA B C， CASTAN A T M， SASSI T S S. Standardization of latency and amplitude parameters on brainstem auditory evoked potential recording with narrow band Ichirp stimulus in normal hearing adults[J]. Audiol Commun Res，2020，25：e2268. doi：10.1590/2317-6431-2019-2268 .
12	MATTIAZZI Â L， CÓSER P L， ENDRUWEIT BATTISTI I D， et al. Auditory brainstem response electrophysiological thresholds with narrow band chirps stimuli in hearing infants[J]. Int J Pediatr Otorhinolaryngol，2023，164：111417. doi：10.1016/j.ijporl.2022.111417 .
13	COBB K M， STUART A. Neonate auditory brainstem responses to CE-chirp and CE-chirp octave band stimuli Ⅰ： Versus click and tone burst stimuli[J]. Ear Hear，2016，37（6）：710-723. doi：10.1097/AUD.0000000000000343 .
14	PINTO J D， MOTTA FORNECK L L， FERREIRA L， et al. Auditory brainstem response with the iChirp stimuli in the infant’s audiological diagnosis[J]. Int J Pediatr Otorhinolaryngol，2022，154：111042. doi：10.1016/j.ijporl.2022.111042 .
15	MALOFF E S， HOOD L J. A comparison of auditory brain stem responses elicited by click and chirp stimuli in adults with normal hearing and sensory hearing loss[J]. Ear Hear，2014，35（2）：271-282. doi：10.1097/AUD.0b013e3182a99cf2 .
16	王小亚，罗仁忠，蓝军，等. 儿童chirp听性脑干反应与行为测听的相关性[J].中华耳鼻咽喉头颈外科杂志，2009，44（3）：188-191. doi：10.3760/cma.j.issn.1673-0860.2009.03.003 .
	WANG X Y， LUO R Z， LAN J， et al. Correlation between chirp auditory brainstem response and behavioral hearing threshold in children[J]. Zhonghua Er Bi Yanhou Toujing Waike Zazhi，2009，44（3）：188-191.
17	罗香林，李楚凌，尹宝珠，等. 听力异常儿童Chirp-ABR与click-ABR波V阈值相关性研究[J].听力学及言语疾病杂志，2015，23（2）：200-201. doi：10.3969/j.issn.1006-7299.2015.02.23 .
	LUO X L， LI C L， YIN B Z， et al. Research on the correlation between wave V thresholds of Chirp-ABR and click-ABR in children with hearing abnormalities[J]. Tinglixue Ji Yanyu Jibing Zazhi，2015，23（2）：200-201.
18	赵金晓，罗玲，史文迪. 听力损失儿童倍频程CE-Chirp听性脑干反应与行为测听相关性分析[J].中国耳鼻咽喉头颈外科，2018，25（2）：83-85. doi：10.16066/j.1672-7002.2018.02.007 .
	ZHAO J X， LUO L， SHI W D. Correlative analysis of octave band CE-Chirp ABR and behavioral auditory in children with hearing loss[J]. Zhongguo Er Bi Yanhou Toujing Waike，2018，25（2）：83-85.
19	汪晓锋，高兴强. 听力正常成人CE-Chirp声与click声听性脑干反应特征比较[J].中国耳鼻咽喉头颈外科，2016，23（10）：613-614. doi：10.16066/j.1672-7002.2016.10.016 .
	WANG X F， GAO X Q. Comparison of auditory brainstem response characteristics between CE-Chirp and click in adults with normal hearing[J]. Zhongguo Er Bi Yanhou Toujing Waike，2016，23（10）：613-614.
20	STUART A， COBB K M. Effect of stimulus and number of sweeps on the neonate auditory brainstem response[J]. Ear Hear，2014，35（5）：585-588. doi：10.1097/AUD.0000000000000066 .
21	CHO S W， HAN K H， JANG H K， et al. Auditory brainstem responses to CE-Chirp® stimuli for normal ears and those with sensorineural hearing loss[J]. Int J Audiol，2015，54（10）：700-704. doi：10.3109/14992027.2015.1043148 .
22	PARLAK A F， KÖYCÜ A， ERBEK H S. Normative auditory brainstem response values to chirp stimulus in adults with normal hearing[J]. Tr-ENT，2018，28（3）：132-140. doi：10.5606/Tr-ENT.2018.29392 .
23	RODRIGUES G R IVO， LEWIS D R. Comparison of click and CE-chirp^® stimuli on brainstem auditory evoked potential recording[J]. Revista da Sociedade Brasileira de Fonoaudiologia，2012，17（4）：412-416. doi：10.1590/S1516-80342012000400008 .
24	李楚凌，罗香林，尹宝珠，等. 听力正常儿童chirp声与click声听性脑干反应特征比较[J].听力学及言语疾病杂志，2014，22（6）：582-584. doi：10.3969/j.issn.1006-7299.2014.06.006 .
	LI C L， LUO X L， YIN B Z， et al. Clinical features comparison of auditory brainstem response by chirp and click stimuli in normal hearing children[J]. Tinglixue Ji Yanyu Jibing Zazhi，2014，22（6）：582-584.
25	CEBULLA M， SHEHATA-DIELER W. ABR-based newborn hearing screening with MB11 BERAphone® using an optimized chirp for acoustical stimulation[J]. Int J Pediatr Otorhinolaryngol，2012，76（4）：536-543. doi：10.1016/j.ijporl.2012.01.012 .
26	王远明，李楚凌，罗香林，等. CE-Chirp声诱发的听性脑干反应对婴幼儿听力损失诊断的价值及临床运用分析[J].中国医药导报，2017，14（33）：111-113，125.
	WANG Y M， LI C L， LUO X L， et al. Diagnostic value of CE-Chirp ABR in infants with suspected hearing loss and clinical application analysis[J]. Zhongguo Yiyao Daobao，2017，14（33）：111-113，125.
27	DI SCIPIO E， MASTRONARDI L. CE-Chirp^® ABR in cerebellopontine angle surgery neuromonitoring： Technical assessment in four cases[J]. Neurosurg Rev，2015，38（2）：381-384，discussion 384. doi：10.1007/s10143-015-0609-3 .
28	LIBERMAN M C， KUJAWA S G. Cochlear synaptopathy in acquired sensorineural hearing loss： Manifestations and mechanisms[J]. Hear Res，2017，349：138-147. doi：10.1016/j.heares.2017.01.003 .
29	MORIMOTO T， FUJISAKA Y I， OKAMOTO Y， et al. Rising-frequency chirp stimulus to effectively enhance wave-Ⅰ amplitude of auditory brainstem response[J]. Hear Res，2019，377：104-108. doi：10.1016/j.heares.2019.03.016 .
30	国家市场监督管理总局，国家标准化管理委员会. 听觉功能障碍法医临床鉴定技术规范： [S].北京：中国标准出版社，2024.
	State Administration for Market Regulation， Standardization Administration of the People’s Republic of China. Technical specification for forensic clinical identification of hearing dysfunction： [S]. Beijing： Standards Press of China，2024.
31	程荷英，李春晓，张运阁，等. NBCE-chirp 40 Hz ASSR反应阈与纯音听阈的比较研究及在司法鉴定中的应用分析[J].中国司法鉴定，2019（2）：32-36. doi：10.3969/j.issn.1671-2072.2019.02.006 .
	CHENG H Y， LI C X， ZHANG Y G， et al. A comparative study of NBCE-chirp 40 Hz ASSR response threshold and pure tone hearing threshold and its application in forensic expertise[J]. Zhongguo Sifa Jianding，2019（2）：32-36.
32	程荷英，张运阁，陈燕，等. 成人CE-Chirp ABR反应阈与纯音听阈相关分析与比较[J].法医学杂志，2024，40（1）：15-19. doi：10.12116/j.issn.1004-5619.2021.210101 .
	CHENG H Y， ZHANG Y G， CHEN Y， et al. Correlation analysis and comparison of adult CE-Chirp ABR response threshold and pure tone hearing threshold[J]. Fayixue Zazhi，2024，40（1）：15-19.
33	FERM I， LIGHTFOOT G， STEVENS J. Comparison of ABR response amplitude， test time， and estimation of hearing threshold using frequency specific chirp and tone pip stimuli in newborns[J]. Int J Audiol，2013，52（6）：419-423. doi：10.3109/14992027.2013.769280 .
34	KOUSHT M EL， MINAWY M S EL， DESSOUKY T M EL， et al. The sensitivity of the CE-Chirp auditory brainstem response in estimating hearing thresholds in different audiometric configurations[J]. Egypt J Otolaryngol，2019，35：56-62. doi：10.4103/ejo.ejo_27_18 .
35	FERM I， LIGHTFOOT G. Further comparisons of ABR response amplitudes， test time， and estimation of hearing threshold using frequency-specific chirp and tone pip stimuli in newborns： Findings at 0.5 and 2 kHz[J]. Int J Audiol，2015，54（10）：745-750. doi：10.3109/14992027.2015.1058978 .
36	范利华，孙红，朱广友，等. 应用40 Hz听觉相关电位与听性脑干反应评估听阈[J].法医学杂志，2000，16（4）：193-195. doi：10.3969/j.issn.1004-5619.2000.04.001 .
	FAN L H， SUN H， ZHU G Y， et al. Evaluation of hearing thresholds of 40 Hz auditory event related potential and auditory brainstem response[J]. Fayixue Zazhi，2000，16（4）：193-195.
37	王琰，段博，许政敏. 听障儿童Chirp-ABR及ASSR与行为测听的相关性研究[J].听力学及言语疾病杂志，2020，28（2）：145-148. doi：10.3969/j.issn.1006-7299.2020.02.007 .
	WANG Y， DUAN B， XU Z M. Comparison between Chirp-ABR， ASSR and behavioral audiometry in children with hearing impairment[J]. Tinglixue Ji Yanyu Jibing Zazhi，2020，28（2）：145-148.
38	刘霞，陈芳，杨小萍，等. 听力障碍的法医学评定标准解读[J].中国法医学杂志，2021，36（6）：581-584. doi：10.13618/j.issn.1001-5728.2021.06.007 .
	LIU X， CHEN F， YANG X P， et al. Interpretation of forensic medical assessment of the hearing disorders[J]. Zhongguo Fayixue Zazhi，2021，36（6）：581-584.
39	KRUMBHOLZ K， HARDY A J， DE BOER J. Automated extraction of auditory brainstem response latencies and amplitudes by means of non-linear curve registration[J]. Comput Methods Programs Biomed，2020，196：105595. doi：10.1016/j.cmpb.2020.105595 .
40	MCKEARNEY R M， MACKINNON R C. Objective auditory brainstem response classification using machine learning[J]. Int J Audiol，2019，58（4）：224-230. doi：10.1080/14992027.2018.1551633 .
41	CHEN C， ZHAN L， PAN X， et al. Automatic recognition of auditory brainstem response characteristic waveform based on bidirectional long short-term memory[J]. Front Med （Lausanne），2020，7：613708. doi：10.3389/fmed.2020.613708 .
42	MCKEARNEY R M， SIMPSON D M， BELL S L. Automated wave labelling of the auditory brainstem response using machine learning[J]. Int J Audiol，2024：1-6. doi：10.1080/14992027.2024.2404537 .

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