Study on the analysis of methamphetamine and its metabolite amphetamine in blood and urine

Abstract

Abstract: The methods using GC/MS,GC/FID,GC/NPD, foridentification and quantification of Methampheta- mined(MAMP) and Amphetamine (AMP) in humanblood and urine were developed. Using 4-phenylbutylamine as the intemal standard, thesamples were extracted with 200μl cyclohexane andthen the 2μl cyclohexane was injected into GC orthe extracts were derivaized by using microwaveirradiation. The methods allowed allowed simple andrapid procedure, the recoveries were greater than80% and the sensitivity limits were 2-5ng/ml.Themethods for d/L Enantiomer of MAMP and AMP inhuman urine was also described, which can be usedto determine the source of Amphetamines anddetermine the toxic effect in the case.

Key words: amphetamines, enantiomer, microwave irradiation, GC/MS, GC/FID, GC/NPD

SHEN MIN ET AL (INSTITUTE OF FORENSIC SCIENCES;MINISTRY OF JUSTICE;000). Study on the analysis of methamphetamine and its metabolite amphetamine in blood and urine[J]. , 1997, 0(3): 129-132+.

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Study on the analysis of methamphetamine and its metabolite amphetamine in blood and urine

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